Modulation of Memory Consolidation, Retrieval and Extinction by Brain Histamine
The brain histaminergic system, whose cell bodies are in the tuberomammilary nucleus, regulates various memory types. The best studied is inhibitory avoidance, which depends on histamine H2 receptors in hippocampus and basolateral amygdala, contextual fea
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Patrizio Blandina Maria Beatrice Passani Editors
Histamine Receptors Preclinical and Clinical Aspects
The Receptors Volume 28
Series editor Giuseppe di Giovanni
More information about this series at http://www.springer.com/series/7668
Patrizio Blandina • Maria Beatrice Passani Editors
Histamine Receptors Preclinical and Clinical Aspects
Editors Patrizio Blandina Department of Neuroscience, Psychology Drug Research and Child Health University of Florence Florence, Italy
Maria Beatrice Passani Department of Health Science University of Florence Florence, Italy
The Receptors ISBN 978-3-319-40306-9 ISBN 978-3-319-40308-3 DOI 10.1007/978-3-319-40308-3
(eBook)
Library of Congress Control Number: 2016952257 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
The understanding of the functions of histamine owes much to the ideas of Pier Francesco Mannaioni. This book is dedicated to him, a mentor and a good friend of both of us. Patrizio Blandina and Maria Beatrice Passani
Preface
Vasodilation and contraction of smooth muscles in the gut were the first biological properties of histamine. The name derives from the combination of histo- + amine (tissue amine), and it was first described more than a century ago by Henry H. Dale and Patrick P. Laidlaw. Histamine has long been known to stimulate gastric acid secretion and to cause constriction of the bronchi during anaphylactic shock. Histamine is involved in inflammatory responses and in the generation of pruritus. As part of an immune response to foreign pathogens, histamine released by basophils and mast cells increases the permeability of capillaries to white blood cells and proteins, to allow them to engage pathogens in the infected tissues. Despite e
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