Molecular and Functional Models in Neuropsychiatry

Common neuropsychiatric diseases are associated with significant human and economic cost. The development of more effective treatments requires scientific progress on a broad front and animal models have a vital role to play in these advances, enabli

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About this series Current Topics in Behavioral Neurosciences provides critical and comprehensive discussions of the most significant areas of behavioral neuroscience research, written by leading international authorities. Each volume offers an informative and contemporary account of its subject, making it an unrivalled reference source. Titles in this series are available in both print and electronic formats. With the development of new methodologies for brain imaging, genetic and genomic analyses, molecular engineering of mutant animals, novel routes for drug delivery, and sophisticated cross-species behavioral assessments, it is now possible to study behavior relevant to psychiatric and neurological diseases and disorders on the physiological level. The Behavioral Neurosciences series focuses on ‘‘translational medicine’’ and cutting-edge technologies. Preclinical and clinical trials for the development of new diagnostics and therapeutics as well as prevention efforts are covered whenever possible.

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Jim J. Hagan Editor

Molecular and Functional Models in Neuropsychiatry

Editor Dr. Jim J. Hagan Global Medical Excellence Cluster (GMEC) King’s College London Guy’s Campus, 1.6 Hodgkin Bldg. United Kingdom [email protected]

ISSN 1866-3370 e-ISSN 1866-3389 ISBN 978-3-642-19702-4 e-ISBN 978-3-642-19703-1 DOI 10.1007/978-3-642-19703-1 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2011924781 # Springer-Verlag Berlin Heidelberg 2011 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover illustration: Artistic representation of oscillatory synchrony and timing of neurons in networks by Gyorgy Buzsaki Cover design: Deblik, Berlin Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

For Carole, Luke and Kate

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Preface

Despite decades of research, common neuropsychiatric diseases remain enigmatic and debilitating disorders which are associated with significant human and economic costs. For example, autism and at