Melanin-Concentrating Hormone and Sleep Molecular, Functional and C
This book offers a compilation of papers on the role of melanin-concentrating hormone (MCH) in sleep, sleep disorders and neuroendocrine functions. Leading experts in sleep medicine, psychiatry and neuroendocrinology provide a broad perspective on the fie
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nConcentrating Hormone and Sleep Molecular, Functional and Clinical Aspects
Melanin-Concentrating Hormone and Sleep
S. R. Pandi-Perumal • Pablo Torterolo • Jaime M. Monti Editors
Melanin-Concentrating Hormone and Sleep Molecular, Functional and Clinical Aspects
Editors S. R. Pandi-Perumal Somnogen Canada Inc. Toronto, Ontario, Canada
Pablo Torterolo Department of Physiology, School of Medicine University of the Republic Montevideo, Uruguay
Jaime M. Monti Department of Pharmacology and Therapeutics, School of Medicine Clinics Hospital University of the Republic Montevideo, Uruguay
ISBN 978-3-319-75764-3 ISBN 978-3-319-75765-0 https://doi.org/10.1007/978-3-319-75765-0
(eBook)
Library of Congress Control Number: 2018936749 © Springer International Publishing AG, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by the registered company Springer International Publishing AG part of Springer Nature. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
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Preface
The melanin-concentrating hormone (MCH) is a neuropeptide that was initially isolated from the teleost pituitary as a chromophore modulator by Kawauchi et al. (1983). Twenty years later, Verret et al. described that this neuropeptide has a strong relationship with the generation and maintenance of sleep. Since then, several authors have described the anatomy and physiology of the MCHergic system. Regarding sleep, the MCHergic system is now considered a critical player for both REM and NREM sleep generation. In addition, there is preclinical and clinical evidence suggesting a role of MCH in human pathology. Finally, synthetic MCH-receptor ligands are under stud
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