Molecular Applications in Cytology
This book is intended for practicing pathologists and cytopathologists, as well as for pathology trainees and cytotechnicians. It starts with a detailed description of the extremely important pre-analytical phase for molecular testing followed by a presen
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Molecular Applications in Cytology
Fernando C. Schmitt Editor
Molecular Applications in Cytology
Editor Fernando C. Schmitt Medical Faculty of Porto University Porto Portugal Instituto de Investigação e Inovaçāo em Saúde Universidade do Porto Porto Portugal IPATIMUP, Institute of Molecular Pathology and Immunology of Porto University Porto Portugal
ISBN 978-3-319-74940-2 ISBN 978-3-319-74942-6 (eBook) https://doi.org/10.1007/978-3-319-74942-6 Library of Congress Control Number: 2018948164 © Springer International Publishing AG, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by the registered company Springer International Publishing AG part of Springer Nature. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
To do more with less… this is the great challenge for the pathology in the next decades. Recently many patients are managed based on diagnosis performed in small biopsies or cytology. Molecular techniques in the routine pathology are changing paradigms as did the introduction of immunohistochemistry some decades ago and are preferentially used on histological material. The goal of this book is to demonstrate that most of these techniques can be easily applied to the cytological material. In fact, cytological samples present numerous advantages over histological material. These include the ability to check the quality of the tissue immediately after harvesting, better preservation of RNA/DNA and the possibility of conducting extensively genomic studies on small amounts of cytological material obtained by fine-needle aspiration or from effusions, urine, among others. In turn, this minimizes the need for more invasive procedures and allows for more frequent re- sampling enabling monitoring of the disease along the
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