Molecular Basis of Resilience Adapting to a Changing Environment
This book illuminates mechanisms of resilience. Threats and defense systems lead to adaptive changes in gene expression. Environmental conditions may dampen adaptive responses at the level of RNA expression. The first seven chapters elaborate t
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Molecular Basis of Resilience
Adapting to a Changing Environment
Molecular Basis of Resilience
Patrick L. Iversen
Molecular Basis of Resilience Adapting to a Changing Environment
Patrick L. Iversen LS Pharma Oregon State University Grand Jct, CO, USA
ISBN 978-3-319-98163-5 ISBN 978-3-319-98164-2 (eBook) https://doi.org/10.1007/978-3-319-98164-2 Library of Congress Control Number: 2018955467 © Springer Nature Switzerland AG 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
I spent over 40 years involved in diverse biological research projects. Each project focused my attention to explore subjects in greater depth. The diversity exemplified differences in ecological studies from molecular biology and studies at the organismal level. Each discipline is made of a community of talented investigators that create a distinct culture and inherent boundaries. My enthusiasm led to a desire to work across boundaries such as joining molecular biology with pharmacology and infectious disease with toxicology. Reflection has revealed a ribonucleic acid as a common feature naturally integrating core elements of multiple disciplines. The bulk of my career involved RNA-based therapeutics. Initially, the concept was limited to disruption of the “Central Dogma” by interfering with translation of mRNA to protein. A compelling transition to oligonucleotide-induced exon- skipping expanded therapeutic options and paralleled the growing appreciation of the importance that transcription of most of our DNA genome to RNA that does not encode protein. However, once I observed oligonucleotide induced translation start- site shifting, I realized significant limitations in simply evaluating RNA expre
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