Molecular Biophysics for the Life Sciences
This volume of the series Biophysics for the Life Sciences focuses on the conceptual framework and major research tools of contemporary molecular biophysics. It is designed to enable non-specialists—both students and professionals in other fields—to
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Norma M. Allewell Linda O. Narhi Ivan Rayment Editors
Molecular Biophysics for the Life Sciences
Biophysics for the Life Sciences Series Editor Norma M. Allewell
For further volumes: http://www.springer.com/series/10230
Norma M. Allewell • Linda O. Narhi Ivan Rayment Editors
Molecular Biophysics for the Life Sciences
Editors Norma M. Allewell Department of Cell Biology and Molecular Genetics University of Maryland College Park, MD, USA
Linda O. Narhi Research & Development Amgen, Inc. Thousand Oaks, CA, USA
Ivan Rayment Department of Biochemistry University of Wisconsin-Madison Madison, WI, USA
ISBN 978-1-4614-8547-6 ISBN 978-1-4614-8548-3 (eBook) DOI 10.1007/978-1-4614-8548-3 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2013949607 © Springer Science+Business Media New York 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
The scope, accessibility, impact, and relevance of biophysics to many different areas of inquiry have grown tremendously in recent years, driven by major conceptual advances, innovations in instrumentation, and powerful new analytical, computational, genomic, and imaging methods. These advances enable us to visualize the structures and dynamics of proteins and nucleic acids at atomic r
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