Molecular Genetics of Liver Neoplasia
Cancer is a genetic disease and cancer research is a broad discipline embracing investigators and clinicians with diverse backgrounds. This new edition of Molecular Genetics of Liver Neoplasia intends to provide a comprehensive view on genetics and a mech
- PDF / 8,164,911 Bytes
- 390 Pages / 439.37 x 666.142 pts Page_size
- 66 Downloads / 220 Views
Series Editor Elaine Ostrander
For further volumes, go to http://www.springer.com/series/7706
Xin Wei Wang · Joe W. Grisham · Snorri S. Thorgeirsson Editors
Molecular Genetics of Liver Neoplasia
123
Editors Xin Wei Wang National Institute of Health Bethesda, MD 20892, USA [email protected]
Joe W. Grisham University of North Carolina at Chapel Hill Chapel Hill, NC 27599, USA [email protected]
Snorri S. Thorgeirsson National Institute of Health Bethesda, MD 20892, USA [email protected]
ISBN 978-1-4419-6081-8 e-ISBN 978-1-4419-6082-5 DOI 10.1007/978-1-4419-6082-5 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010937690 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Primary liver cancer is the third most deadly and fifth most common cancer worldwide, with an estimated 877,000 new cases and almost as many deaths in 2007. Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major types of primary liver cancer. The 5 year survival rate of these cancers is less than 10% and during the last 50 years only minimal survival improvement has been realized. Although liver cancer is most frequent in sub-Saharan Africa and Asia, the incidence has increased sharply in the developed countries in recent years. The key etiological factors (i.e., Hepatitis B and C viruses, obesity, and type 2 diabetes) are known for HCC, but the etiological causes for CC are less well-defined. Furthermore, our current understanding of the molecular pathogenesis of primary liver cancer is still far from complete. Therefore, there is an urgent need for more comprehensive genetic and mechanistic understanding of primary liver cancer if improvements in treatment and prevention are to be realized. Recent progress in the genetic and genomic understanding of liver cancer has generated both excitement and hope that this knowledge
Data Loading...
