Molecular Pathways and Animal Models of Total Anomalous Pulmonary Venous Return
The venous pole of the heart where the pulmonary veins will develop encompasses the sinus venosus and the atrium. In the 4th week of development, the sinus venosus consists of a left and a right part receiving blood from the common cardinal vein, the omph
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genital Heart Diseases: The Broken Heart Clinical Features, Human Genetics and Molecular Pathways
Congenital Heart Diseases: The Broken Heart
Silke Rickert-Sperling 2OBERT ' +ELLY s $AVID * $RISCOLL %DITORS
Congenital Heart Diseases: The Broken Heart Clinical Features, Human Genetics AND -OLECULAR 0ATHWAYS
Editors Silke Rickert-Sperling Cardiovascular Genetics Charité - Universitätsmedizin Berlin Berlin Germany
David J. Driscoll Department of Pediatrics Division of Pediatric Cardiology Mayo Clinic College of Medicine Rochester, MN USA
Robert G. Kelly Developmental Biology Institute of Marseilles Aix-Marseille Université Marseille France Editorial Assistant Andreas Perrot Cardiovascular Genetics Charité - Universitätsmedizin Berlin Berlin Germany
ISBN 978-3-7091-1882-5 ISBN 978-3-7091-1883-2 DOI 10.1007/978-3-7091-1883-2
(eBook)
Library of Congress Control Number: 2015958767 Springer Wien Heidelberg New York Dordrecht London © Springer-Verlag Wien 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer-Verlag GmbH Wien is part of Springer Science+Business Media (www.springer.com)
This book is dedicated to my mentors Hanno D. Schmidt, Peter E. Lange, and Hans Lehrach. Their training, support, and encouragement have made this book possible. Silke Rickert-Sperling
Foreword
As is indicated in its title, the book you are about to read is concerned with the congenitally malformed heart. Approximately eight neonates in every thousand born alive present with such a “broken heart”. This number has changed little since Maude Abbott, when describing the first plate in her Atlas devoted to congenitally malformed hearts, commented that “An understanding of the elementary facts of human and comparative embryology is essential to an intelligent grasp of the ontogenetic problems of congenital cardiac disease”. Paul Dudley White, when writing the foreword to her Atlas, commented that it had been left to Abbott to “make the subject one of such gene
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