Monte Carlo simulation of dose distribution in water around 57 Fe 3 O 4 magnetite nanoparticle in the nuclear gamma reso
- PDF / 1,370,200 Bytes
- 10 Pages / 439.642 x 666.49 pts Page_size
- 10 Downloads / 160 Views
Monte Carlo simulation of dose distribution in water around 57 Fe3 O4 magnetite nanoparticle in the nuclear gamma resonance condition R. Gabbasov1 · M. Polikarpov1 · V. Safronov2 · E. Sozontov1 · A. Yurenya1,3 · V. Panchenko1,3
© Springer International Publishing Switzerland 2016
Abstract In this work was proposed a new radiotherapy enhancement method consisting of the administration of magnetic nanoparticles into the cells with further irradiation with a gamma-ray beam. As a result, adjusting the energy distribution of a gamma-ray beam and 57 Fe abundance it is possible to achieve an extremely intensive electron emission because of a nuclear resonance. The produced conversion and Auger electrons can be used as an effective tool for DNA lesions production. We developed a Monte Carlo model for an electron and gamma emission by 57 Fe nucleus using the Geant4 program package. The parameters of a resonant absorption were taken from M¨ossbauer spectra of magnetite nanoparticles synthesized for the administration into live cells. The space distribution of the radiation dose showed an increase in the dose of 2–2.5 times in the case of the natural abundance and more than 50 times in the case of the 66 % enrichment of the nanoparticles. Keywords Brachytherapy · Monte-Carlo model · magnetic nanoparticles · M¨ossbauer effect · radiotherapy · Auger electrons
1 Introduction Ionizing radiation is considered to be one of the most effective tools for oncological disease treatment. There are two traditional types of radiotherapy: irradiation of tumor with This article is part of the Topical Collection on Proceedings of the International Conference on the Applications of the M¨ossbauer Effect (ICAME 2015), Hamburg, Germany, 13–18 September 2015 A. Yurenya
[email protected] 1
National Research Centre Kurchatov Institute, Moscow, Russia
2
Research Center Space Materials Science, Shubnikov Institute of Crystallography, Kaluga, Russia
3
Lomonosov Moscow State University, Moscow, Russia
34
Page 2 of 10
Hyperfine Interact (2016) 237:34
external source and direct implantation of materials, containing radioactive source, into a tumor body, so called brachytherapy [1]. Irradiating of tumor with external source is conjugated with irradiation both malignant and healthy tissues. This fact limits tolerant dose of common therapy procedure and may cause serious side effects. Brachytherapy methods allow delivering requisite radiation dose more directly to the target region, than distant therapy, especially in case of internal organ tumors disposed deep under the skin. Nevertheless, there are many problems associated with brachytherapy treatment, such as difficulties with administration of radioactive implants inside body with its extraction and its potential toxicity, together with uncontrolled irradiation of healthy tissues remains tangible [2, 3]. Ideal radiotherapy treatment implies efficient irradiation the whole of tumor cells without any harm to healthy tissues. Both traditional radiotherapy approaches are nonspecific to
Data Loading...
