Morphine
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Angioedema following sublingual administration in an elderly patient: case report An 85 year-old patient [sex not clearly stated], with terminal Alzheimer’s dementia, developed generalised increase in tone and agitation. Treatment with muscle relaxants and lorazepam was ineffective. The patient’s symptoms were thought to be caused by pain and a trial of low-dose sublingual morphine 2.5mg every 4 hours was initiated. The next day, sudden swelling of the tongue and lips developed, as well as a snoring-type noise on breathing. Examination revealed oedema of the face, tongue, lips and pharynx. Morphine-induced angioedema was suspected. Morphine was withdrawn and the patient received methylprednisolone. The angioedema resolved completely. Upon recurrence of the patient’s agitation, fentanyl was administered with good results. Kohli R, et al. Morphine induced angioedema. Annual Scientific Meeting of the American Geriatrics Society (2011) : abstr. A22, 30 May 2011. Available from: 801160293 URL: http://www.acog.org - USA
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Reactions 21 May 2011 No. 1352
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