Morphological and Functional Peculiarities of the Immune System of Male and Female Rats with Different Hypoxic Resistanc
- PDF / 1,267,067 Bytes
- 6 Pages / 594 x 792 pts Page_size
- 36 Downloads / 225 Views
Bulletin of Experimental Biology and Medicine, Vol. 169, No. 6, October, 2020
825
MORPHOLOGY AND PATHOMORPHOLOGY Morphological and Functional Peculiarities of the Immune System of Male and Female Rats with Different Hypoxic Resistance D. Sh. Dzhalilova, A. M. Kosyreva, I. S. Tsvetkov, N. A. Zolotova, V. A. Mkhitarov, L. P. Mikhailova, and O. V. Makarova
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 6, pp. 773-778, June, 2020 Original article submitted April 6, 2020 The morphological and functional peculiarities of the immune system are studied in adult male and female Wistar rats with high and low hypoxic resistance. Sex-specific differences in the subpopulation composition of the peripheral blood lymphocytes, not depending on the hypoxic resistance of animals, are detected: the males have lower absolute counts of T helpers and higher percentage of regulatory T cells than the females in the diestrus phase. Comparison of the morphofunctional status of the immune system in male and female (diestrus) rats with high resistance to hypoxia has shown a better developed subcapsular zone of the thymus, higher levels of anti-inflammatory cytokine TGF-β, and lower absolute counts of cytotoxic T lymphocytes in the peripheral blood in the males. Males with low hypoxic resistance have higher counts of phase II thymic bodies in comparison with low-resistant females. Hence, morphofunctional differences in the immune system of male and female rats with different hypoxic resistance are detected, which can determine the course of inflammatory diseases. Key Words: hypoxia; sex-specific differences; immune system; rats Sex-specific differences in the resistance to oxygen deficiency have been described not once. Female rats are more resistant to hypoxia than the males. For example, the females sooner restore breathing after hypoxic exposure [9]. Sex-specific differences in the regulation of respiration and incidence of respiratory infections are detected. Repeated apnea and hypopnea are 3-fold more incident in men than in women [10]. Studies of hypoxia are usually carried out on males, while in females, the phase of the estrous cycle is neglected. We have previously shown some differences between rats with low and high resistance to hypoxia Research Institute of Human Morphology, Moscow, Russia. Address for correspondence: [email protected]. D. Sh. Dzhalilova
(LR and HR, respectively): LR males are characterized by higher expression of HIF-1α factor and VEGF angiogenesis factor mRNA in the liver, higher absolute counts of cytotoxic T-lymphocytes and NK cells in the peripheral blood, and greater volume fraction of the marginal zone of the splenic lymphoid nodules [7,8]. The LR females in the diestrus phase are characterized by higher level of anti-inflammatory cytokine TGF-β and absolute count of NK cells in the peripheral blood and a lesser volume fraction of the cortical matter in the thymus than HR females [2]. The morphology and function of the immune system largely determine the mechanisms and
Data Loading...
