Morphometric evaluation of cerebellar structures in late monocular blindness
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ORIGINAL PAPER
Morphometric evaluation of cerebellar structures in late monocular blindness ¨ zkan O ¨ zen . Fatih Aslan O
Received: 16 June 2020 / Accepted: 29 October 2020 Ó Springer Nature B.V. 2020
Abstract Background Only a few studies have investigated structural and functional changes in monocular blind individuals. Our aim in this study was to segmentally investigate the cerebellar structures of subjects with late-onset monocular blindness (LMB) using a Voxelbased volumetric analysis system. Methods The segmental volumetric values, cortical thickness, gray matter volumes and percentage ratios of the cerebellar lobules of individuals with LMB due to trauma and in healthy individuals with bilateral sight as the control group were calculated at the volBrain CERES 1.0 website (https://volbrain.upv.es/) by using brain 3D fast spoiled gradient recall acquisition in steady-state (3D T1 FSPGR) MRI sequence images in our prospective study. Results We studied 11 subjects with LMB (8 males/3 females) and 11 healthy control subjects (8 males/3 females). The mean age was 41.45 ± 14.15 and 40 ± 11.11 years, respectively (p [ 0.05). The mean duration of the LMB status was 20.8 ± 11.2 years. ¨. O ¨ zen O Department of Radiology, Alaaddin Keykubat University Alanya Education and Research Hospital, Antalya 07400, Turkey F. Aslan (&) Department of Ophthalmology, Alaaddin Keykubat University Alanya Education and Research Hospital, Antalya 07400, Turkey e-mail: [email protected]
Cerebellar lobule crus II volume and cerebellar lobule VIIB/VIIIA volume/percentage were higher in the LMB group, and mean cerebellar cortical thickness, cerebellar lobule VI-cerebellar lobule crus I-II cortical thickness, and cerebellar lobule VI gray matter volume values were lower in the LMB group (p \ 0.05). Conclusion In this study, cerebellar lobule VIIB/ VIIIA volume/total percent ratio, cerebellar cortical thickness and cerebellar gray matter volume in the LMB group were found to be different from the control group. To our knowledge, this is the first study to report cerebellar anatomical changes in patients with LMB. Keywords Cerebellum Magnetic resonance imaging Monocular blindness Visuospatial cognition
Introduction The World Health Organization defines low vision as a visual impairment that hinders the person’s ability to perform daily living activities and that cannot be corrected with glasses, contact lenses, or surgery [1]. Severe visual impairment and blindness are categorized as less than 20° or less than 10°, respectively, according to the degree of central visual field limitation [2, 3]. Most states accept 20/200 or less in the
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better eye after maximum correction as the threshold of blindness. One study from 2010 reported that 32.4 million people were blind worldwide [4]. Blindness can be caused by various ocular disorders such as age-related macular degeneration, glaucoma, diabetic retinopathy, cataract, and ocular injuries. Vision loss not only
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