Morphometric Parameters of the Lung Tissue in Isolated Musculoskeletal Injuries under Conditions of Moderate Hyperhomocy
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Bulletin of Experimental Biology and Medicine, Vol. 169, No. 5, September, 2020 MORPHOLOGY AND PATHOMORPHOLOGY
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Morphometric Parameters of the Lung Tissue in Isolated Musculoskeletal Injuries under Conditions of Moderate Hyperhomocysteinemia Yu. I. Pigolkin1, D. B. Nikityuk2, I. I. Kuznetsov1, D. P. Berezovskii1, and S. S. Bachurin1
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 5, pp. 657-660, May, 2020 Original article submitted January 23, 2020 The combination of inherited and acquired factors of increased thrombosis complicates establishing the cause-effect relationships between mechanical injury and death during forensic medical examination. Morphometric parameters of the lung tissue and pulmonary vessels in isolated mechanical trauma under conditions of moderate hyperhomocysteinemia were studied in an experiment on laboratory animals. A regularity in changes of the morphometry para meters of the pulmonary vessels was found. Morphometric changes in the wall of pulmonary parenchyma veins can be used as an additional marker to assess the causal relationship between isolated mechanical injury and fatal complication in the form of pulmonary embolism. Key Words: hyperhomocysteinemia; isolated limb injury; thrombophilia; forensic medical examination Prevention, diagnosis and treatment of thromboembolic complications is still an urgent task of medicine. Forensic experts face the problem of venous thromboembolic complications in cases of sudden death and when establishing causal relationships between the mechanical injury or surgery and subsequent fatal pulmonary embolism. Venous thromboembolic complications are a multifactor pathological process. Venous endothelial dysfunction is a risk factor for increased thrombosis. In turn, the increased procoagulation activity of the vascular endothelium could be a consequence of high blood concentration of homocysteine (HC) of inherited or acquired origin. At the same time, traumas of the lower limb segments are a transient (acquired) factor of hypercoagulation [5]. The combination of inherited and acquired factors of increased thrombosis causes natural difficulties for I. M Sechenov First Moscow State Medical University, the Ministry of Health of the Russian Federation (Sechenov University); 2Federal Research Center for Nutrition and Biotechnology, Moscow, Russia. Address for correspondence: [email protected]. D. P. Berezovskii 1
medical examiners in establishing cause-and-effect relationships between mechanical injury and death. This leads to the search for new markers (including morphological) that allow differentiating the leading pathogenetic link in the development of a fatal complication after mechanical injury. The changes in the lung tissue and microvasculature of the lungs in isolated trauma of the musculoskeletal system under conditions of moderate hyperhomocysteinemia (HHC) are poorly systematized and described in scientific literature. Here we studied morphometric parameters of the lung tissue and pulmonary vessels of laboratory
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