Mouse Brain Development
With the enormous development of human and mouse genomics and the availability of a variety of transgenic techniques, the mouse has become the most widely used animal for basic studies of brain development and as a model for human developmental disorders.
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Andre M. Goffinet . Pasko Rakic (Eds.)
Mouse Brain Development
With 69 Figures
Springer
ANDRE
M.
GOFFINET
Neurobiology Unit University of Namur Medical School 61, rue de Bruxelles B-5000 Namur Belgium PASKO RAKIC
Section of Neurobiology Yale University School of Medicine 333, Cedar Street New Haven, cr 06510
ISSN 0080-1844 ISBN 978-3-642-53684-7 Library of Congress Cataloging-in-Pulication Data Mouse brain development / Andre M. Goffinet, Pasko Rakie (eds.) p. cm. -- (Results and Problems in Cell Differentiation; 30) Includes bibliographieal references. ISBN 978-3-642-53684-7 ISBN 978-3-540-48002-0 (eBook) DOI 10.1007/978-3-540-48002-0 1. Developmental neurobiology. 2. Mice as laboratory animals. I. Goffinet, A. 11. Rakic, Pasko, 1933- 11. Series.
QP363.5 .M68 2000 573.8'619353--dc21 Ihis work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publieation or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer-Verlag is a company in the BertelsmannSpringer publishing group. © Springer-Verlag Berlin Heidelberg 2000 Softcover reprint of the hardcover 1st edition 2000 Ihe use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover design: Meta Design, Berlin Iypesetting: Scientific Publishing Services (P) LId., Madras SPIN: 10681947 39/3136 - 5 4 3 2 1 0 - Printed on acid-free paper
Preface
Our understanding of the molecular mechanisms involved in mammalian brain development remains limited. However, the last few years have witnessed a quantum leap in our knowledge, due to technological improvements, particularly in molecular genetics. Despite this progress, the available body of data remains mostly phenomenological and reveals very little about the grammar that organizes the molecular dictionary to articulate a phenotype. Nevertheless, the recent progress in genetics will allow us to contemplate, for the first time, the integration of observation into a coherent view of brain development. Clearly, this may be a major challenge for the next century, and arguably is the most important task of contemporary developmental biology. The purpose of the present book is to provide an overview that synthesizes up-to-date information on selected aspects of mouse brain development. Given the format, it was not possible to cover all aspects of brain de
