Mouse Models of Vascular Diseases
This book is a methodological source on mice models of vascular diseases. Covering various areas, each chapter is written by a pioneering researcher who has developed an original vascular disease model. Notoriously difficult to reproduce, each model is de
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Mouse Models of Vascular Diseases
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Masataka Sata Editor
Mouse Models of Vascular Diseases
Editor Masataka Sata Tokushima University Tokushima, Japan
ISBN 978-4-431-55811-8 ISBN 978-4-431-55813-2 DOI 10.1007/978-4-431-55813-2
(eBook)
Library of Congress Control Number: 2016931990 © Springer Japan 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by SpringerNature The registered company is Springer Japan KK.
Preface
There are many patients who are suffering from various types of vascular diseases. Atherosclerosis results in luminal narrowing and insufficient blood perfusion, leading to organ damage such as myocardial infarction, cerebral infarction, and amputation of lower extremities. Atherosclerotic diseases are a leading cause of death in industrialized countries. Obstructive atherosclerotic diseases are treated by percutaneous catheter intervention or bypass surgery, which requires subsequent re-vascularization procedures due to re-stenosis of the target lesion or a bypass graft in many cases. Aortic aneurysm and cerebral aneurysm may cause sudden death by unanticipated rupture. Graft vasculopathy—diffuse intimal hyperplasia in arteries of the transplanted organs—causes grant failure. Moreover, coronary aneurysm is the major sequel of Kawasaki’s disease, a mucocutaneous lymph node syndrome in children. Unfortunately, exact pathogenesis of most of the vascular diseases remains to be clarified. Subsequently, there are no established methods to diagnose and prevent those vascular diseases accurately. Genetically modified mice are a very powerful tool for studying the pathogenesis of various diseases, including immunology, oncology, the central nervous system, autoimmune disease, and congenital diseases. Genetically modified mice also provide good tools to track the origin and the fate of the cells that play a key role in the disease process. However, mice had always been
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