MRI-based Parcellation and Morphometry of the Individual Rhesus Monkey Brain: the macaque Harvard-Oxford Atlas (mHOA), a
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ORIGINAL RESEARCH
MRI-based Parcellation and Morphometry of the Individual Rhesus Monkey Brain: the macaque Harvard-Oxford Atlas (mHOA), a translational system referencing a standardized ontology R. Jarrett Rushmore 1,2,3 & Sylvain Bouix 2 & Marek Kubicki 2,3 & Yogesh Rathi 2,3 & Douglas L. Rosene 1 & Edward H. Yeterian 2,3,4 & Nikos Makris 1,2,3
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Investigations of the rhesus monkey (Macaca mulatta) brain have shed light on the function and organization of the primate brain at a scale and resolution not yet possible in humans. A cornerstone of the linkage between non-human primate and human studies of the brain is magnetic resonance imaging, which allows for an association to be made between the detailed structural and physiological analysis of the non-human primate and that of the human brain. To further this end, we present a novel parcellation method and system for the rhesus monkey brain, referred to as the macaque Harvard-Oxford Atlas (mHOA), which is based on the human Harvard-Oxford Atlas (HOA) and grounded in an ontological and taxonomic framework. Consistent anatomical features were used to delimit and parcellate brain regions in the macaque, which were then categorized according to functional systems. This system of parcellation will be expanded with advances in technology and, like the HOA, will provide a framework upon which the results from other experimental studies (e.g., functional magnetic resonance imaging (fMRI), physiology, connectivity, graph theory) can be interpreted. Keywords Ontology . macaque monkey . cortical parcellation . MRI . HOA . mHOA
Abbreviations CGa anterior cingulate CGp posterior cingulate CP coronal plane COa central operculum- anterior COp central operculum - posterior
Edward H. Yeterian and Nikos Makris contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11682-020-00357-9) contains supplementary material, which is available to authorized users. * Nikos Makris [email protected] 1
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA
2
Psychiatry Neuroimaging Laboratory, Brigham and Women’s Hospital, Boston, MA, USA
3
Center for Morphometric Analysis, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, MA 02129, USA
4
Department of Psychology, Colby College, Waterville, ME, USA
F1dl F1dm F2 FOC FP INS ITG LPCi LPCs MPC PO PoG PRL PHG PrG SC STG STP STRdl STRm TP VMO
dorso-lateral superior frontal dorso-medial superior frontal inferior frontal fronto-orbital frontal pole insula inferior temporal gyrus inferior portion of lateral parietal cortex superior portion of lateral parietal cortex medial parietal cortex parietal operculum postcentral gyrus prelunate parahippocampal gyrus precentral gyrus subcallosal area superior temporal gyrus supratemporal plane dorsolateral portion of striate cortex medial portion of striate cortex temporal pole ventromedia
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