mtDNA Copy Number Contributes to All-Cause Mortality of Lacunar Infarct in a Chinese Prospective Stroke Population
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ORIGINAL ARTICLE
mtDNA Copy Number Contributes to All-Cause Mortality of Lacunar Infarct in a Chinese Prospective Stroke Population Li Song 1 & Tianlong Liu 2 & Yan Song 1 & Yingying Sun 1 & Hao Li 1 & Ning Xiao 1 & Haochen Xu 1 & Jing Ge 1 & Congxia Bai 1 & Hongyan Wen 1 & Yinhui Zhang 1 & Rutai Hui 1 & Jingzhou Chen 1 Received: 5 September 2019 / Accepted: 27 November 2019 # Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract The study aimed to investigate the relationship between mtDNA copy number and the risk of all-cause mortality in stroke. One thousand four hundred eighty-four stroke patients were documented including 273 deaths (127 thrombosis, 52 lacunar, 94 hemorrhage). Patients in the third quartile had the lowest mortality rates in overall stroke and the three subtypes. The lowest quartile of mtDNA copy number (Q1 < 85.85) indicated an increased risk of all-cause mortality in stroke patients (adjusted HR, 1.52; 95% CI, 1.08–2.14; p = 0.017). In the subtype analysis, the risk of all-cause mortality appeared only in lacunar infarct, and the patients in the Q1 (< 87.76) and Q4 (> 150.61) mtDNA copy number groups showed significantly higher risks of HRs (Q1, adjusted HR, 3.87, 95% CI, 1.52–9.83; Q4, adjusted HR, 3.08, 95% CI, 1.16–8.18). Stroke patients with lacunar infarct in mtDNA copy number < 87.76 or > 150.61 were at a high risk of poor outcomes in all-cause mortality. Keywords Stroke . Mitochondrial DNA copy number . All-cause mortality . Lacunar infarct
Abbreviations ROS Reactive oxygen species mtDNA Mitochondrial DNA BMI Body mass index SBP Systolic blood pressure DBP Diastolic blood pressure TC Total cholesterol HDL-C High-density lipoprotein cholesterol TG Triglyceride DM Diabetes mellitus RCS Restricted cubic spline HR Hazard ratio CI Confidence interval
Li Song and Tianlong Liu contributed equally to this work. Associate Editor Junjie Xiao oversaw the review of this article * Jingzhou Chen [email protected] 1
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
2
Department of Pharmacy, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China
Introduction Stroke is the leading cause of mortality and disability worldwide. The prevalence of stroke has increased during the past 30 years in China [1]. Because China is an aging society with a large proportion of elderly individuals, both the occurrence of stroke and the recurrence of stroke impose substantial burdens on patients, families, and the whole society [2]. Identifying the risk factors for stroke may lead to effective primary and secondary prevention [3, 4]. Mitochondria are the “cellular power plants” and are responsible for multiple cellular functions, including energy metabolism, the generation of reactive oxygen species (ROS), calcium homeostasis, cell proliferation, and apoptosis [5–9]. Excessive ROS damages proteins, DNA, and lipids, thereby i
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