An Association Study on Renalase Polymorphisms and Ischemic Stroke in a Chinese Population
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ORIGINAL PAPER
An Association Study on Renalase Polymorphisms and Ischemic Stroke in a Chinese Population Ruyou Zhang • Xiaoying Li • Nana Liu • Xijuan Guo • Wei Liu • Chunping Ning • Zhenzhen Wang • Litao Sun • Songbin Fu
Received: 12 January 2013 / Accepted: 16 March 2013 / Published online: 6 April 2013 Ó Springer Science+Business Media New York 2013
Abstract Ischemic stroke is a leading cause of death and adult disability worldwide. Recent research suggests that renalase is strongly associated with heart disease and hypertension and may play a role in ischemic stroke. In this study, we investigate the genetic association between renalase and ischemic stroke in a northern Chinese Han population. We genotyped single-nucleotide polymorphisms of the renalase gene in 507 ischemic stroke patients and 503 gender-matched controls from a northern Chinese Han population, and we classified these case samples in depth by complications with diabetes or hypertension and by ischemic stroke subtypes. We undertook allele, genotype, and haplotype association studies in all the cases and in the subgroups, as well as multiple factor analysis by logistic regression. rs10887800 and rs2576178 were
Ruyou Zhang, Xiaoying Li, and Nana Liu: Co first authors R. Zhang Department of Neurosurgery, The 2nd Affiliated Hospital of Harbin Medical University, No. 246, Xuefu Road, Nangang District, Harbin 150081, Heilongjiang, People’s Republic of China X. Li N. Liu X. Guo W. Liu Z. Wang L. Sun (&) Department of Ultrasound, The 2nd Affiliated Hospital of Harbin Medical University, No. 246, Xuefu Road, Nangang District, Harbin 150081, Heilongjiang, People’s Republic of China e-mail: [email protected] C. Ning The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China S. Fu (&) Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China e-mail: [email protected]
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significantly associated with ischemic stroke with hypertension by logistic regression (p = 0.041 and p = 0.038, respectively). The recessive model showed a strong association of rs2296545 with ischemic stroke patients in hypertension subgroups (OR = 1.927, 95 % CI = 1.012– 3.669, p = 0.046). The renalase gene is closely related to ischemic stroke in this northern Chinese Han population, suggesting that renalase may be mechanistically involved in stroke pathology. Keywords Ischemic stroke Renalase SNPs Association studies Logistic regression
Introduction Ischemic stroke is a leading cause of death and adult disability worldwide (Lopez et al. 2006; Matsushita et al. 2010; Truelsen et al. 2006). In China, millions of people have suffered a stroke (Suarez and Ruilope 1999). Accumulating evidence suggests that ischemic stroke is a complicated clinical syndrome, with a number of components being involved in its pathological mechanism, including genetic predisposition and environmental factors (Dichgans 2007). Twin and familial aggregation studies have shown that genetics other than general risk factors is conducive to i
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