Multimodal Neuroimaging in Schizophrenia: Description and Dissemination
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DATA ORIGINAL ARTICLE
Multimodal Neuroimaging in Schizophrenia: Description and Dissemination C. J. Aine 1,2 & H. J. Bockholt 1,3,4 & J. R. Bustillo 5 & J. M. Cañive 5,6 & A. Caprihan 1 & C. Gasparovic 1 & F. M. Hanlon 1 & J. M. Houck 1 & R. E. Jung 7 & J. Lauriello 8 & J. Liu 1 & 9 A. R. Mayer 1 & N. I. Perrone-Bizzozero & S. Posse 10,11,12 & J. M. Stephen 1 & J. A. Turner 13 & V. P. Clark 1,9,14 & Vince D. Calhoun 1,5,9,11
# The Author(s) 2017. This article is an open access publication
Abstract In this paper we describe an open-access collection of multimodal neuroimaging data in schizophrenia for release to the community. Data were acquired from approximately 100 patients with schizophrenia and 100 age-matched controls during rest as well as several task activation paradigms targeting a hierarchy of cognitive constructs. Neuroimaging data include structural MRI, functional MRI, diffusion MRI, MR spectroscopic imaging, and magnetoencephalography. For three of the hypothesis-driven projects, task activation paradigms were acquired on subsets of ~200 volunteers which examined a range of sensory and cognitive processes (e.g., auditory sensory gating, auditory/visual multisensory integration, visual transverse patterning). Neuropsychological data were also acquired and genetic material via saliva samples were collected from most of the participants and have been typed for both genome-wide polymorphism data as well as genome-wide methylation data. Some results are also presented from the individual studies as well as from our data-driven
multimodal analyses (e.g., multimodal examinations of network structure and network dynamics and multitask fMRI data analysis across projects). All data will be released through the Mind Research Network’s collaborative informatics and neuroimaging suite (COINS). Keywords Neuroimaging . Schizophrenia . fMRI . MEG . Magnetoencephalography . Spectroscopy . Genetics . Sensory gating . Multimodal integration . Memory . Transverse patterning . DTI . ICA . COINS . COBRE . MATRICS
Introduction The purpose of this paper is to announce the release of a large multimodal neuroimaging dataset on chronic schizophrenia patients and healthy controls [e.g., functional MRI, diffusion 6
New Mexico VA Health Care System, Albuquerque, NM, USA
7
Department of Neurosurgery, University of New Mexico SOM, Albuquerque, NM, USA
8
Department of Psychiatry, University of Missouri Health Care, Columbia, MO, USA
9
The Mind Research Network, 1101 Yale Blvd NE, Albuquerque, NM 87106, USA
Department of Neurosciences, University of New Mexico SOM, Albuquerque, NM, USA
10
Department of Radiology, University of New Mexico SOM, Albuquerque, NM, USA
Department of Neurology, University of New Mexico SOM, Albuquerque, NM, USA
11
Department of Electrical and Computer Engineering, Albuquerque, NM, USA
3
Advanced Biomedical Informatics, LLC, Coralville, IA, USA
12
Department of Physics and Astronomy, Albuquerque, NM, USA
4
Department of Psychiatry, University of Iowa, SOM, Iowa City, IA, USA
13
Depar
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