Mutant p53 and MDM2 in Cancer
This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the under
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Swati Palit Deb Sumitra Deb Editors
Mutant p53 and MDM2 in Cancer
Mutant p53 and MDM2 in Cancer
Subcellular Biochemistry Volume 85
Series editor Robin Harris, Northumberland, UK
For further volumes: http://www.springer.com/series/6515
Swati Palit Deb • Sumitra Deb Editors
Mutant p53 and MDM2 in Cancer
Editors Swati Palit Deb Sumitra Deb Department of Biochemistry and Molecular Biology, and the Massey Cancer Center Virginia Commonwealth University
Richmond, VA, USA
ISSN 0306-0225 ISBN 978-94-017-9210-3 ISBN 978-94-017-9211-0 (eBook) DOI 10.1007/978-94-017-9211-0 Springer Dordrecht Heidelberg New York London Library of Congress Control Number: 2014946109 © Springer Science+Business Media Dordrecht 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Since its discovery, p53 research has been the highlight of understanding the crucial role of oncogenes and tumor suppressors in regulated or deregulated cell growth. In the last decade, special attention was focused on gain of function mutations of p53 that can turn the tumor suppressor to an oncoprotein, as well as on abnormal expression of oncogenes such as MDM2 and MDMX that could inactivate the tumor suppressor function of p53 in the hope of devising cancer treatment. A wealth of information h
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