p53
Our understanding of human cancer in the past 40 years has been driven by linking innovative concepts and cutting edge technologies to key problems identified by clinical research. Some of the successes in cancer genetics identified from clinical work hav
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p53 Ayeda Ayed, PhD Ontario Cancer Institute University of Toronto Toronto, Ontario, Canada
Theodore Hupp, PhD Institute of Genetics and Molecular Medicine CRUK p53 Signal Transduction Laboratories University of Edinburgh Edinburgh, Scotland, UK
LANDES BIOSCIENCE AUSTIN, TEXAS USA
SPRINGER SCIENCE+BUSINESS MEDIA NEW YORK, NEW YORK USA
p53 Molecular Biology Intelligence Unit Landes Bioscience Springer Science+Business Media, LLC ISBN: 978-1-4419-8230-8
Printed on acid-free paper.
Copyright ©2010 Landes Bioscience and Springer Science+Business Media, LLC All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher, except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in the publication of trade names, trademarks, service marks and similar terms even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the authors, editors and publisher believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, are in accord with current recommendations and practice at the time of publication, they make no warranty, expressed or implied, with respect to material described in this book. In view of the ongoing research, equipment development, changes in governmental regulations and the rapid accumulation of information relating to the biomedical sciences, the reader is urged to carefully review and evaluate the information provided herein. Springer Science+Business Media, LLC, 233 Spring Street, New York, New York 10013, USA. http://www.springer.com Please address all inquiries to the Publishers: Landes Bioscience, 1806 Rio Grande, Austin, Texas 78701, USA. Phone: 512/ 637 6050; FAX: 512/ 637 6079 http://www.landesbioscience.com Printed in the United States of America. 9 8 7 6 5 4 3 2 1
Library of Congress Cataloging-in-Publication Data p53 / [edited by] Ayeda Ayed, PhD, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada, Theodore Hupp, PhD, Institute of Genetics and Molecular Medicine, CRUK p53 Signal Transduction Laboratories, University of Edinburgh, Edinburgh, Scotland, UK. p. ; cm. -- (Molecular biology intelligence unit) Includes bibliographical references and index. ISBN 978-1-4419-8230-8 (alk. paper) 1. p53 antioncogene. 2. p53 protein. I. Ayed, Ayeda, 1962- editor. II. Hupp, Theodore, 1969- editor. III. Series: Molecular biology intelligence unit (Unnumbered : 2003) [DNLM: 1. Cell Transformation, Neoplastic--genetics. 2. Genes, p53. QZ 202] RC268.44.P16P15 2011 572.8'6--dc22 2010046107
About the Editors...
AYEDA AYED is on leave from the Ontario Cancer Institute at the University of Toronto where she worked as a Postdoctoral Fellow and Asso
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