Myocardial sympathetic innervation, function, and oxidative metabolism in non-infarcted myocardium in patients with prio
- PDF / 337,005 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 23 Downloads / 175 Views
ORIGINAL ARTICLE
Myocardial sympathetic innervation, function, and oxidative metabolism in non-infarcted myocardium in patients with prior myocardial infarction Hirofumi Aoki • Ichiro Matsunari • Yusuke Nomura • Wataru Fujita • Ryoko Komatsu • Yoshiharu Miyazaki Stephan G. Nekolla • Kouji Kajinami
•
Received: 20 February 2013 / Accepted: 3 March 2013 / Published online: 14 March 2013 Ó The Japanese Society of Nuclear Medicine 2013
Abstract Objective The purpose of this study was to investigate the relationship between sympathetic innervation, contractile function, and the oxidative metabolism of the non-infarcted myocardium in patients with prior myocardial infarction. Methods In 19 patients (14 men, 5 women, 65 ± 9 years) after prior myocardial infarction, sympathetic innervation was assessed by 11C-hydroxyephedrine (HED) positron emission tomography (PET). Oxidative metabolism was quantified using 11C-acetate PET. Left ventricular systolic function was measured by echocardiography with speckle tracking technique. Results The 11C-HED retention was positively correlated with left ventricular ejection fraction (LVEF) (r = 0.566, P \ 0.05), and negatively with peak longitudinal strain in systole in the non-infarcted myocardium (r = -0.561, P \ 0.05). Kmono, as an index of oxidative metabolism, was significantly correlated with rate pressure product (r = 0.649, P \ 0.01), but not with 11C-HED retention (r = 0.188, P = 0.442). Furthermore, there was no significant correlation between Kmono and LVEF (r = 0.106, P = 0.666) or peak longitudinal strain in systole (r = -0.256, P = 0.291) in the non-infarcted myocardium. H. Aoki Y. Nomura W. Fujita K. Kajinami Department of Cardiology, Kanazawa Medical University, Uchinada, Ishikawa, Japan I. Matsunari (&) R. Komatsu Y. Miyazaki Clinical Research Department, The Medical and Pharmacological Research Center Foundation, Wo 32, Inoyama, Hakui, Ishikawa 925-0613, Japan e-mail: [email protected] S. G. Nekolla Department of Nuclear Medicine, Technical University Munich, Munich, Germany
When the patients were divided into two groups based on the median value of left ventricular end-systolic volume index (LVESVI) (41 mL), there were no significant differences in age, sex, and rate pressure product between the groups. However, the large LVESVI group ([41 mL) was associated with reduced 11C-HED retention and peak longitudinal strain in systole, whereas Kmono was similar between the groups. Conclusions This study indicates that remodeled LV after myocardial infarction is associated with impaired sympathetic innervation and function even in the non-infarcted myocardial tissue. Furthermore, oxidative metabolism in the non-infarcted myocardium seems to be operated by normal regulatory mechanisms rather than pre-synaptic sympathetic neuronal function. Keywords Sympathetic innervation Oxidative metabolism Myocardial infarction Speckle tracking echocardiography Positron emission tomography
Introduction Despite recent advances in therapeutic options, heart failure due
Data Loading...
