Myoepithelioma of the soft palate: Review of the literature and report of a case with immunohistochemical study
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Hellenic Journal of Surgery (2014) 86:1, 42-46
Myoepithelioma of the Soft Palate: Review of the Literature and Report of a Case With Immunohistochemical Study A. Klimis, M. Philipou
Abstract Background: Myoepitheliomas of the salivary glands are rare neoplasms accounting for less than 1.5% of all salivary
gland tumours. They are classified into four cell types: spindle, clear, epithelioid and plasmacytoid. The plasmacytoid cell type appears to have a predilection for the oral cavity, especially the palate. Case presentation: A 56-year-old man was admitted to the ENT department complaining of a painless soft palate
mass that had shown progressive growth over the past 9 months. At oral examination, a firm, nodular, ovoid-shaped lesion measuring 2.5cm in diameter with a well-delimited border,was palpated at the posterior midline portion of the soft palate. The overlying mucosa was intact. Computed tomography (CT) showed a hypodense tumour image. The clinical picture was suggestive of a tumour of the small salivary glands. The patient underwent a complete surgical resection of the tumour. The latter was located in the submucosa. It consisted of polygonal cells with round, eccentric nuclei and eosinophilic cytoplasm. Focal necrosis was not observed. The mitotic index was 2/10 high-power fields. Immunohistochemically, the tumour cells showed positivity for S-100 protein, vimentin, GFAP and negativity for CK 14 and SMA. The immunoreactivity of Ki-67 was sporadic, confirming the diagnosis of benign myoepithelioma. Conclusion: Myoepithelioma composed predominantly of plasmacytoid myoepithelial cells is a rare neoplasm that
occurs in the soft palate. Wide excision with tumour-free margins is the treatment of choice. Key words: Myoepithelioma, plasmacytoid, soft palate, immunohistochemical study
Introduction Myoepithelioma (ME) of the salivary glands is a rare benign neoplasm, accounting for less than 1.5% of all salivary gland tumours [1-4]. Of all the salivary gland myoepitheliomas, 26% involve the minor salivary glands of the oral cavity, with the palate being the most common origin of intraoral myoepitheliomas [2-6]. These tumours are classified into four cell types: epithelioid, clear, spindle and plasmacytoid. Among them, the plasmacytoid cell type appears to have a predilection for the oral cavity, especially the palate. Similar to most benign salivary gland tumours, myoepitheliomas most often present as slowly enlarging asymptomatic masses [4-7]. A. Klimis Department of the Pathology1, Prefectural General Hospital “Polikliniki”, Athens,Greece M. Philipou Department of ΕΝΤ, “Pammakaristos” Hospital of Divine Providence, Athens, Greece Correspondent Author: A. Klimis M.D. Department of Pathology, Prefectural General Hospital “Polikliniki”, Athens,Greece, Tel.: 210-7561841, 6930943475, Fax: 210-7561841 E-mail: [email protected] Received 5 Sept 2013; Accepted 10 Oct 2013
Hellenic Journal of Surgery 86
Herein, we describe the case of plasmacytoid myoepithelioma arising in the soft palate as confirmed by i
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