Nanoparticle-Loaded Polarized-Macrophages for Enhanced Tumor Targeting and Cell-Chemotherapy
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ARTICLE
Cite as Nano-Micro Lett. (2021) 13:6 Received: 5 July 2020 Accepted: 2 September 2020 © The Author(s) 2020
https://doi.org/10.1007/s40820-020-00531-0
Nanoparticle‑Loaded Polarized‑Macrophages for Enhanced Tumor Targeting and Cell‑Chemotherapy Teng Hou1, Tianqi Wang1, Weiwei Mu1, Rui Yang1, Shuang Liang1, Zipeng Zhang1, Shunli Fu1, Tong Gao1, Yongjun Liu1 *, Na Zhang1 *
HIGHLIGHTS • A polarized-macrophages-based drug delivery system (M1/SLNP) was presented for the cell-chemotherapy of cancer. • Polarized-macrophages were used both as therapeutic tool to provide immunotherapy and as delivery vessel to target deliver chemotherapeutic drugs to tumor tissues for chemotherapy simultaneously. • M1/SLNP was a multifunctional delivery system with simple structure, excellent safety, and without complex synthesis process.
ABSTRACT Cell therapy is a promising strategy for cancer therapy. However,
its therapeutic efficiency remains limited due to the complex and immunosup-
Polarization
pressive nature of tumor microenvironments. In this study, the “cell-chemotherapy” strategy was presented to enhance antitumor efficacy. M1-type mac-
SLNP
Macrophages
rophages, which are therapeutic immune cells with both of immunotherapeutic
M1/SLNP
Tumor targeting
ability and targeting ability, carried sorafenib (SF)-loaded lipid nanoparticles (M1/SLNPs) were developed. M1-type macrophages were used both as therapeutic tool to provide immunotherapy and as delivery vessel to target deliver SF to tumor tissues for chemotherapy simultaneously. M1-type macrophages
y
rap
the
mo
Che
SF
were obtained by polarizing macrophages using lipopolysaccharide, and M1/ SLNPs were obtained by incubating M1-type macrophages with SLNP. Tumor
Cytokines Ce
accumulation of M1/SLNP was increased compared with SLNP (p
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