NanoScience in Biomedicine

NanoScience in Biomedicine provides up-to-date information in the frontier fields of nano biomedicine focusing on basic concepts and recent developments in many topical areas including particular nanomaterials synthesis, field emission of carbon nanotubes

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NanoScience in Biomedicine

Donglu Shi

NanoScience in Biomedicine

With 292 figures

EDITOR: Donglu Shi Department of Chemical and Materials Engineering, College of Engineering, University of Cincinnati, Cincinnati, OH 45221, USA The Institute for Advanced Materials and Nano Biomedicine, Tongji University, Shanghai 200092, China Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China

_______________________________________________________________ ISBN 978-7-302-17905-4 Tsinghua University Press, Beijing ISBN 978-3-540-49660-1 Springer Berlin Heidelberg New York e ISBN 978-3-540-49661-8 Springer Berlin Heidelberg New York _______________________________________________________________ Library of Congress Control Number: pending This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable to prosecution under the German Copyright Law. © 2009 Tsinghua University Press, Beijing and Springer-Verlag GmbH Berlin Heidelberg Co-published by Tsinghua University Press, Beijing and Springer-Verlag GmbH Berlin Heidelberg Springer is a part of Springer Science+Business Media springer.com The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover design: Frido Steinen-Broo, EStudio Calamar, Spain Printed on acid-free paper

Preface

The research on nanomaterials and nano biomedicine has been advancing rapidly in recent years, particularly in the development of unique nanostructures for specific biomedical applications. The research addresses the critical issues in medical applications including in vivo imaging, cell targeting, local drug delivery and treatment, bioactivity, compatibility, and toxicity. In the biomedical applications, traditional materials science and engineering have to deal with new challenges in the areas of synthesis, structure development, and biological, chemical, and physical behaviors, since medical needs place new demands in these respects. The novel nanotechnologies included in this book are of great importance for biomedical applications. Based on these new developments, it is possible to alter the intrinsic properties of nanomaterials that cannot be achieved by conventional methods and materials. A key aspect of being able to manipulate the properties of the nanomaterials is the nanoscale architecture and engineering by various processing techniques. Some of