Necrotising soft tissue infections and NSAID use
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Necrotising soft tissue infections and NSAID use There is a strong association between NSAID use and severe necrotising soft tissue infection (NSTI), according to results of a case-control study. The researchers identified 38 cases of NSTI and 228 matched controls from the French Pharmacovigilance database between January 2000 and December 2004. Of the 38 cases, 12 were infants (0–23 months), 16 were children (2–15 years) and 10 were adults (> 15 years). Of the 28 children, 22 had received NSAIDs, 26 had varicella and two had other viral infections. Of the 10 adults, none had a known viral infection and six had received NSAIDs. Following multivariate analysis, the researchers found significant associations between NSTI and NSAIDs (odds ratio [OR] 31.38) and NSTI and viral infections (OR 17.55). The researchers note that the presence of varicella in most of the patients "constitutes another limitation in investigating the individual role of NSAIDs, as varicella could itself be complicated by necrotizing infection with or without use of NSAIDs". Souyri C, et al. Severe necrotizing soft-tissue infections and nonsteroidal antiinflammatory drugs. Clinical and Experimental Dermatology 33: 249-255, No. 3, 801111013 May 2008
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Reactions 28 Jun 2008 No. 1208
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