Nerve growth factor is closely related to glucose metabolism, insulin sensitivity and insulin secretion in the second tr
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RESEARCH
Nerve growth factor is closely related to glucose metabolism, insulin sensitivity and insulin secretion in the second trimester: a case–control study in Chinese Mengyang Tang1,2†, Mingjuan Luo1,2,3†, Wenqian Lu1,2, Rong Zhang4, Wei Liang3, Jianfen Gu3, Xuemei Yu1,2, Xueli Zhang1,2 and Cheng Hu1,2,4*
Abstract Objective: Inflammation-related factors have been shown to play a significant role throughout pregnancy. In this study, we aimed to explore the relationships between selected inflammatory cytokines and gestational diabetes (GDM) in Chinese pregnant women. Design and methods: This was a 1:1 matched case–control study that included 200 pairs of subjects in the second trimester and 130 pairs of subjects in the third trimester. Serum levels of nerve growth factor (NGF), Interleukin-6 (IL-6), leptin, Interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α) and Interleukin-1beta (IL-1β) were measured by enzyme immunoassay. The associations of these inflammatory factors with metabolic parameters were analysed. Results: In the second trimester, GDM patients had higher NGF levels and lower IL-8 levels than did normal controls (P
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