Nerve Growth Factor Regulated Gene Expression
This chapter provides a current accounting of the identities of genes and gene products that are subject to long-term regulation by nerve growth factor (NGF). We provide tabular listings of (a) NGF-responsive genes and proteins that are reported in the li
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Nerve Growth Factor Regulated Gene Expression
L. A. Greene . J. M. Angelastro
1 Overall Aim and Content of This Chapter . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 2 The Role of Regulated Gene Expression in the NGF Mechanism—What Genes Does NGF Regulate and Why Do We Want to Know? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 3 Regulation of Gene Expression by NGF—A View from the Literature . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 4 Long‐Term Regulation of Gene Expression by NGF—Results of a SAGE Study with PC12 Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 5 Closing Remarks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52
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2008 Springer ScienceþBusiness Media, LLC.
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Nerve growth factor regulated gene expression
Abstract: This chapter provides a current accounting of the identities of genes and gene products that are subject to long‐term regulation by nerve growth factor (NGF). We provide tabular listings of (a) NGF‐ responsive genes and proteins that are reported in the literature and (b) transcripts found by comprehensive serial analysis of gene expression (SAGE) to be differentially expressed in PC12 cells before and after long‐term NGF exposure. Transcriptional changes are key elements in the mechanisms by which NGF affects neuronal differentiation, function, protection, and repair. The information provided here is thus meant to serve as a resource for those interested in the molecular mechanisms and consequences of trophic factor actions. List of Abbreviations: ATF5, activating transcription factor 5; EST, expressed sequence tag; NGF, nerve growth factor; SAGE, serial analysis of gene expression
1 Overall Aim and Content of This Chapter The aim of this chapter is to provide a current account of what we know about the identities of the genes and gene products that are subject to long‐term regulation by NGF. Our objective is like that of traditional handbooks of chemistry and physics, that is, to list information without including extensive interpretive rhetoric. We hope that the reader will find this information to be a useful resource that will inspire further experimental and intellectual advances regarding the development, function, and repair of the nervous system. There are two principal portions of this chapter. One is a tabular listing of the genes and gene products that have been identified in the literature as being regulated by NGF. The second is a tabular listing of identified NGF regulated transcripts that we have detected in a large‐scale SAGE comparison of the transcriptomes of naı¨ve and long‐term NGF‐treated PC12 cells. In each case, the regulated genes have been subdivided into cate
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