Neuroanatomy and Pathology of Sporadic Alzheimer's Disease
As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its
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Heiko Braak Kelly Del Tredici
Neuroanatomy and Pathology of Sporadic Alzheimer's Disease
Reviews and critical articles covering the entire field of normal anatomy (cytology, histology, cyto- and histochemistry, electron microscopy, macroscopy, experimental morphology and embryology and comparative anatomy) are published in Advances in Anatomy, Embryology and Cell Biology. Papers dealing with anthropology and clinical morphology that aim to encourage cooperation between anatomy andrelated disciplines will also be accepted. Papers are normally commissioned. Original papers and communications may be submitted and will be considered for publication provided they meet the requirements of a review article and thus fit into the scope of “Advances”. English language is preferred. It is a fundamental condition that submitted manuscripts have not been and will not simultaneously be submitted or published elsewhere. With the acceptance of a manuscript for publication, the publisher acquires full and exclusive copyright for all languages and countries.
Manuscripts should be addressed to
Co-ordinating Editor Prof. Dr. H.-W. KORF , Zentrum der Morphologie, Universität Frankfurt, Theodor-Stern Kai 7, 60595 Frankfurt/Main, Germany e-mail: [email protected]
Editors Prof. Dr. T.M. BÖCKERS, Institut für Anatomie und Zellbiologie, Universität Ulm, Ulm, Germany e-mail: [email protected] Prof. Dr. F. CLASCÁ, Department of Anatomy, Histology and Neurobiology Universidad Autónoma de Madrid, Ave. Arzobispo Morcillo s/n, 28029 Madrid, Spain e-mail: [email protected] Dr. Z. KMIEC, Department of Histology and Immunology, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland e-mail: [email protected] Prof. Dr. B. SINGH, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada e-mail: [email protected] Prof. Dr. P. SUTOVSKY, S141 Animal Science Research Center, University of Missouri, Columbia, MO, USA e-mail: [email protected] Prof. Dr. J.-P. TIMMERMANS, Department of Veterinary Sciences, University of Antwerpen, Groenenborgerlaan 171, 2020 Antwerpen, Belgium e-mail: [email protected]
215 Advances in Anatomy, Embryology and Cell Biology
Co-ordinating Editor H.-W. Korf, Frankfurt
Series Editors T.M. Bo¨ckers • F. Clasca´ • Z. Kmiec B. Singh • P. Sutovsky • J.-P. Timmermans More information about this series at http://www.springer.com/series/102
Heiko Braak • Kelly Del Tredici
Neuroanatomy and Pathology of Sporadic Alzheimer’s Disease With 48 figures
Heiko Braak Kelly Del Tredici Zentrum f. Biomed. Forschung AG Klinische Neuroanatomie/Abteilung Neurologie Universita¨t Ulm Ulm Germany
ISSN 0301-5556 ISSN 2192-7065 (electronic) ISBN 978-3-319-12678-4 ISBN 978-3-319-12679-1 (eBook) DOI 10.1007/978-3-319-12679-1 Springer Cham Heidelberg New York Dordrecht London Library of Congress Control Number: 2014957640 # Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the
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