Calcium Signalling and Disease Molecular Pathology of Calcium
This topic is a new entry in the area of cellular calcium signaling: yet, it now spans the entire area, with discoveries that cover both genetic and acquired pathologies, even offering glimpses in the direction of therapy. Cellular calcium homeostasis, an
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SUBCELLULAR BIOCHEMISTRY SERIES EDITOR J.ROBIN HARRIS, University of Mainz, Mainz, Germany
ASSISTANT EDITORS B.B. BISWAS, University of Calcutta, Calcutta, India P.QUINN, King’s College London, London, U.K Recent Volumes in this Series Volume 31
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alpha-Gal and Anti-Gal: alpha-1,3-Galactosyltransferase, alpha-Gal Epitopes and the Natural Anti-Gal Antibody Edited by Uri Galili and Jos-Luis Avila
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Bacterial Invasion into Eukaryotic Cells Tobias A. Oelschlaeger and Jorg Hacker
Volume 34
Fusion of Biological Membranes and Related Problems Edited by Herwig Hilderson and Stefan Fuller
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Enzyme-Catalyzed Electron and Radical Transfer Andreas Holzenburg and Nigel S. Scrutton
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Phospholipid Metabolism in Apoptosis Edited by Peter J. Quinn and Valerian E. Kagan
Volume 37
Membrane Dynamics and Domains Edited by P.J. Quinn
Volume 38
Alzheimer’s Disease: Cellular and Molecular Aspects of Amyloid beta Edited by R. Harris and F. Fahrenholz
Volume 39
Biology of Inositols and Phosphoinositides Edited by A. Lahiri Majumder and B.B. Biswas
Volume 40
Reviews and Protocols in DT40 Research Edited by Jean-Marie Buerstedde and Shunichi Takeda
Volume 41
Chromatin and Disease Edited by Tapas K. Kundu and Dipak Dasgupta
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Inflammation in the Pathogenesis of Chronic Diseases Edited by Randall E. Harris
Volume 43
Subcellular Proteomics Edited by Eric Bertrand and Michel Faupel
Volume 44
Peroxiredoxin Systems Edited by Leopold Flohé and J. Robin Harris
Volume 45
Calcium Signalling and Disease Edited by Ernesto Carafoli and Marisa Brini
Calcium Signalling and Disease Molecular Pathology of Calcium Subcellular Biochemistry Volume 45 Edited by
Ernesto Carafoli University of Padova, Italy
and
Marisa Brini University of Padova, Italy
This series is a continuation of the journal Sub-Cellular Biochemistry. Volume 1 to 4 of which were published quarterly from 1972 to 1975
ISBN 978-1-4020-6190-5 (HB) ISBN 978-1-4020-6191-2 (e-book)
© 2007 Springer All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science + Business Media, Inc., 233 Springer street, New York, NY 10013, USA), except for brief excerpts in connection with review or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaption, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks and similar terms, whether or not they are subject to proprietary rights. (BS/DH) 9
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CONTENTS
List of Contributors
vii
Prologue
xi
1.
Annexinopathies M.J. Hayes, R.E. Longbottom, M.A. Evans and S.E. Moss
1
2.
Calpains and Human Disease I. Bertipaglia and E. Carafoli
29
3.
Gelsolin and Diseases L. Spinardi and W. Witke
55
4.
Guanylate Cyclase-Activating Prote
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