Methods of Cancer Diagnosis, Therapy, and Prognosis Ovarian Cancer,

This sixth volume in the series Methods of Cancer Diagnosis, Therapy, and Prognosis discusses Ovarian Cancer, Renal Cancer, Urogenitary Cancer, Urinary Bladder Cancer, Cervical Uterine Cancer, Skin Cancer, Leukemia, Multiple Myeloma and Sarcoma. Both stan

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Methods of Cancer Diagnosis, Therapy, and Prognosis Volume 6

For other titles published in this series, go to www.springer.com/series/8172

Methods of Cancer Diagnosis, Therapy, and Prognosis Volume 6

Ovarian Cancer, Renal Cancer, Urogenitary Tract Cancer, Urinary Bladder Cancer, Cervical Uterine Cancer, Skin Cancer, Leukemia, Multiple Myeloma and Sarcoma Edited by

M.A. Hayat Department of Biological Sciences, Kean University, Union, NJ, USA

Editor M.A. Hayat Department of Biological Sciences Kean University Union, NJ, USA

ISBN 978-90-481-2917-1

e-ISBN 978-90-481-2918-8

Library of Congress Control Number: 2009929394 © 2010 Springer Science + Business Media B.V. No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written ­permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper springer.com

New technology, for better or for worse, will be used, as that is our nature. Lewis Thomas

You have been given the key that opens the gates of heaven; the same key opens the gates of hell. Writing at the entrance to a Buddhist temple

Contributors

Laurent Alberti Centre Léon Bérard, 28, Rue Laennec, 69008 Lyon, France Juan Luis Alcázar Department of Obstetrics and Gynecology, Clínica Universitaria de Navarra, University of Navarra, Avenida Pio XII, 36 Pamplona 31008, Spain Damien Ambrosetti Service d’Anatomie Pathologique, Hôpital Pasteur, 30 Avenue de la Voie Romaine, 06000 Nice, France Yaser Atlasi Department of Genetics, Faculty of Basic Science, Tarbiat Modares University, P.O. Box: 1411-175, Tehran, Iran Allyson C. Baker University of Alabama at Birmingham, NP 3537, 619 19th Street South, Birmingham, AL 35249, USA Surinder K. Batra Department of Biochemistry and Molecular Biology, College of Medicine, Eppley Cancer Institute 7052 Durham Research Center, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198-5870, USA

Vladimir Bilim Department of Urology, Yamagata University Faculty of Medicine, Iida-nishi 2-2-2, Yamagata 990-9585, Japan Michael J. Birrer Cell and Cancer Biology, National Cancer Institute, 37 Convent Drive, Room 1068, Bethesda, MD 20892, USA Jean-Yves Bla INSERM U590, Centre Léon Bérard, Rue Laennec, 69008 Lyon, France Malte Böhm Department of Urology, Otto-vonGuericke Universität, Leipziger Str. 44, D-39120 Magdeburg, Germany Kristin L.M. Boylan Department of Laboratory Medicine and Pathology, The University of Minnesota Medical School, Minneapolis, MN 55455, USA Laura Brousseau Centre Léon Bérard, 28, rue Laennec, 69008 Lyon, France Fanny Burel-Vandenbos Service d’Anatomie Pathologique, Hôpital Pasteur, 30 Avenue de la Voie Romaine, 06000 Nice, France vii

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Gabriel Caponetti Department of Pathology, Baystate Medical Center, Tufts School of