Neuroimmune Pharmacology

The chapters contained in this volume show scientific relationships among historically separated fields. This allows a unique opportunity for scientists and students to gain broad knowledge in disparate fields of clinical medicine and biomedical research.

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Neuroimmune Pharmacology

Edited by Tsuneya Ikezu, M.D., Ph.D. University of Nebraska Medical Center Omaha, NE and

Howard E. Gendelman, M.D. University of Nebraska Medical Center Omaha, NE

Topic Editors Serge Przedborski, M.D., Ph.D. Columbia University New York, NY

Jonathan Kipnis, Ph.D. University of Virginia Charlottesville, VA

Kalipada Pahan, Ph.D. Rush University Chicago, IL

Managing Editor

Alexander V. Kabanov, Ph.D. University of Nebraska Medical Center Omaha, NE

Robin Taylor University of Nebraska Medical Center Omaha, NE

Tsuneya Ikezu, M.D., Ph.D. Department of Pharmacology and Experimental Neuroscience University of Nebraska Medical Center Omaha, NE, 68198-5880 Email: [email protected]

ISBN-13: 978-0-387-72572-7

Howard E. Gendelman, M.D. Department of Pharmacology and Experimental Neuroscience University of Nebraska Medical Center Omaha, NE, 68198-5880 Email: [email protected]

e-ISBN-13: 978-0-387-72573-4

Library of Congress Control Number: 2007940389 © 2008 Springer Science+Business Media, LLC All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY-10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper. 9 8 7 6 5 4 3 2 1 springer.com

Acknowledgments

This interdisciplinary work would not have seen fruition without the tireless, dedicated, and selfless support of one very important person, Robin Taylor. Robin is a driver of details. Her undaunted enthusiasm, drive for excellence and tirelessness inspires all of those who engage and know her. The links between editors, authors, administrators, and publishers have flown seamlessly under her watchful eye. As a managing editor, her skills remain without parallel. Andrea Macaluso and all staff at Springer USA who are inspired leaders in publishing and medical biocommunication. Their leadership directed the need for such a comprehensive and interdisciplinary work but made themselves always available at even a moment’s notice. We are proud to have linked with such talented individuals and ones so dedicated to the pursuit of excellence in all they do. To our leaders and visionaries, John Gollan, Harold Maurer, Thomas Rosenquist, Clarence Ueda, and Carol Swarts, a simple thank you for all your support, through good times and bad, seems too simple. The gift of your ears and your thoughtful responses and unbridled determination to bring out only the best in us is appreciated beyond words.

To our chapter contributors an