Systems Pharmacology and Pharmacodynamics
While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline th
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Donald E. Mager Holly H.C. Kimko Editors
Systems Pharmacology and Pharmacodynamics
AAPS Advances in the Pharmaceutical Sciences Series Volume 23
Editors-in-chief Daan J.A. Crommelin, Utrecht University, Utrecht, Utrecht, The Netherlands Robert A. Lipper, Back Cove Pharma, LLC, Waldoboro, ME, USA
The AAPS Advances in the Pharmaceutical Sciences Series, published in partnership with the American Association of Pharmaceutical Scientists, is designed to deliver volumes authored by opinion leaders and authorities from around the globe, addressing innovations in drug research and development, and best practice for scientists and industry professionals in the pharma and biotech industries.
More information about this series at http://www.springer.com/series/8825
Donald E. Mager Holly H.C. Kimko •
Editors
Systems Pharmacology and Pharmacodynamics
123
Editors Donald E. Mager Department of Pharmaceutical Sciences University at Buffalo, SUNY Buffalo, NY USA
Holly H.C. Kimko Global Clinical Pharmacology Janssen Research & Development, LLC, Spring House, PA USA
ISSN 2210-7371 ISSN 2210-738X (electronic) AAPS Advances in the Pharmaceutical Sciences Series ISBN 978-3-319-44532-8 ISBN 978-3-319-44534-2 (eBook) DOI 10.1007/978-3-319-44534-2 Library of Congress Control Number: 2016948099 © American Association of Pharmaceutical Scientists 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Systems pharmacology, a relatively new discipline, is the interface between systems biology and pharmacodynamics. It is a response to the growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase 2 studies. Systems pharmacology provides a framework fo
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