New polymer systems based on polyethylene glycol: synthesis, characterization, and study of the solubility behavior
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New polymer systems based on polyethylene glycol: synthesis, characterization, and study of the solubility behavior Azar Ghaffari1 · Malihe Pooresmaeil1 · Hassan Namazi1,2 · Ali A. Entezami1 Received: 19 August 2019 / Revised: 2 October 2019 / Accepted: 28 November 2019 © Springer-Verlag GmbH Germany, part of Springer Nature 2019
Abstract Recently due to the exclusive rheological properties and a highly branched structure, star-shaped polymers have received more attention. In the first section of the present work, the polyethylene glycol (PEG)-based star-shaped polymer systems were prepared from the reaction of methoxypolyethylene glycols with various molecular weight as arm and trimesoyl chloride (TMC) as a core. The structure of the synthesized star-shaped polymers confirmed using the Fourier transform infrared spectroscopy and proton nuclear magnetic resonance. The solubility test showed that the synthesized polymers are soluble in water, dimethyl sulfoxide, dimethylformamide, and chlorinated solvents. In the second part of this work, the crosslinked PEGs preparation possibility in the melt state by using the trimesic acid (TMA) and TMC as a crosslinker was investigated. Evaluation of the swelling and solubility behavior of the prepared systems showed that the prepared crosslinked systems with TMA are soluble in most of the organic solvents, while the crosslinked systems with TMC as a crosslinker are insoluble in all of the organic solvents and show the swellability characteristics. From the obtained results it is concluded that the TMC is a better crosslinker for the crosslinking of PEG in the melt state.
* Hassan Namazi [email protected] 1
Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran
2
Research Center for Pharmaceutical Nanotechnology (RCPN), Tabriz University of Medical Science, Tabriz, Iran
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Vol.:(0123456789)
Polymer Bulletin
Graphical abstract
Keywords Polyethylene glycol · Star-shaped polymer · Crosslinked polymers · Trimesoyl chloride · Trimesic acid
Introduction Polymers are one of the very important classes of materials. Over the past decades, polymers with defined architectures received an increasing attention because of the requirement to polymer systems with excellent performances [1–11]. Star-shaped and crosslinked polymer systems are two commonly used polymer architectures in various fields. A wide range of synthetic or natural polymers has been used for the preparation of crosslinked and star-shaped polymer systems. These polymer systems could be formed from both degradable and non-degradable source [12–20]. PEG is one of the water-soluble, non-toxic, biocompatible, and biodegradable polymers which widely have been studied due to its unique properties [21–30]. The PEG usability in many areas such as artificial cells and organs [31], contact lenses [32], wound dressing [33], controlled drug delivery [28, 34], and cosmetic fields [35] has been demonstrated. Moreover, PEG is an applicable polymer
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