Study on the properties of a polymer system based on poly (ethylene glycol), n-isopropyl acrylamide and chitosan for con
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ORIGINAL CONTRIBUTION
Study on the properties of a polymer system based on poly (ethylene glycol), n-isopropyl acrylamide and chitosan for controlled drug delivery Angel Daniel Muñoz Guzman 1 & Martin Rabelero 2 & Abraham Gabriel Alvarado-Mendoza 3 Received: 25 April 2020 / Revised: 31 July 2020 / Accepted: 19 August 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Structured hydrogels with thermo-sensitivity properties to be used as a novel carrier for controlled drug delivery were prepared here. These hydrogels were formed by core-shell particles, where the core is a semi-interpenetrated polymer network (semi-IPN) made of n-isopropylacrylamide (NIPAAm) and poly (ethylene glycol) (PEG), and a chitosan shell. All polymers were synthesized by using semi-continuous heterophase polymerization at different dosing rates to study their effect on particle size, system stability and drug deliver efficiency. Structural (FTIR, particle size, SEM) and functional analysis were performed (stability and drug delivery). FTIR confirmed the polymerization by showing the development of interactions between the characteristic functional groups from the polymers. SEM micrographs from hydrogels revealed a porous structure, which is affected by the dosing rate during the polymerization process as well as the particle size which affect the stability of the obtained latex. Drug release analysis of the hydrogels was performed into distilled water and in a buffer at different temperatures. Results shown that most of the characteristics of this polymer system can be controlled, and so tuning the controlled release behaviour, these findings made these hydrogels an important contender for controlled drug delivery. Keywords Drug delivery . Hydrogel . Emulsion . PEG . NIPAAm . Chitosan
Introduction Polymers have been taking more and more strength due to scientific advances that have occurred in recent years. Research on biocompatible polymers has been increased in different areas such as drug delivery and tissue engineering [1]. They can be synthetized as polymeric nanofibres, due to its high porosity, mechanical properties and substantial ratio of volume to the surface area; these polymeric nanofibres are * Martin Rabelero [email protected] 1
Doctorado en Ciencia de Materiales, Universidad de Guadalajara, Gral. Marcelino García Barragán 1421, 44430 Guadalajara, Jalisco, México
2
Departamento de Ingeniería Química, Universidad de Guadalajara, Gral. Marcelino García Barragán 1421, 44430 Guadalajara, Jalisco, México
3
Departamento de Química, Universidad de Guadalajara, Gral. Marcelino García Barragán 1421, 44430 Guadalajara, Jalisco, México
attractive for potential applications such as tissue engineering [2] or drug delivery as patches [3]. Another way to synthetize these polymers is as nanogels composed with covalent or physical crosslinked hydrophilic polymers [4] and used to deliver biologically active agents and drugs in a controlled and sustained release manner [5]. Biocompatible hydrogels are an excell
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