New Strategies in Stroke Intervention Ionic Transporters, Pumps, and
Ischemic brain damage represents a major source of morbidity and mortality in westernized society and poses a significant financial burden on the health care system. To date, few effective therapies have been realized to treat stroke and pr
- PDF / 5,410,209 Bytes
- 258 Pages / 471.329 x 716.313 pts Page_size
- 41 Downloads / 169 Views
Lucio Annunziato Editor
Contemporary Neuroscience
For further volumes: http://www.springer.com/series/7626
Lucio Annunziato Editor
New Strategies in Stroke Intervention Ionic Transporters, Pumps, and New Channels
Editor Lucio Annunziato Department of Neuroscience School of Medicine ‘‘Federico II’’ University of Naples Via Sergio Pansini, 5 80131 Napoli Italy [email protected]
ISBN 978-1-60761-279-7 e-ISBN 978-1-60761-280-3 DOI 10.1007/978-1-60761-280-3 Library of Congress Control Number: 2009932562 # Humana Press, a part of Springer ScienceþBusiness Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer ScienceþBusiness Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper springer.com
Preface
Stroke is a leading cause of serious, long-term disability in the world. Every 45 seconds someone is affected by stroke and on average every 3–4 min someone dies of focal ischemia. In fact, 15 million people suffer from stroke worldwide each year. Of these, five million die and another five million are permanently disabled. Stroke ranks among the third most common cause of death after heart disease and cancer. In developed countries, the incidence of stroke is declining – largely because of the efforts to lower blood pressure and reduce smoking. However, given that age is one of the most substantiated risk factors for stroke, the aging of the world population implies a growing number of people at risk. The mean lifetime cost of a single ischemic stroke in the US is estimated at $140,048, including impatient care, rehabilitation, and follow-up care for longlasting deficits. The estimated direct and indirect costs of stroke for 2009 are $ 68.9 billion in the United States and $ 32.3 billion in the European Union countries. Stroke is caused by a blood clot that lodges in the brain and reduces oxygen supply to critical tissue. Two general therapeutic approaches are available: the first strategy is aimed at reducing the failure of arterial oxygen and glucose delivery to the local brain tissue by performing a thrombolysis of
Data Loading...
