New Technologies for Toxicity Testing

The central theme running through this volume on New Technologies for Toxicity Testing is the development and application of advanced techniques for cell and tissue culture, as well as new markers and endpoints of toxicity, as alternatives to the traditio

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ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo IRUN R. COHEN, The Weizmann Institute of Science ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research JOHN D. LAMBRIS, University of Pennsylvania RODOLFO PAOLETTI, University of Milan

Recent Volumes in this Series

Volume 737 OXYGEN TRANSPORT TO TISSUE XXXIII Martin Wolf, Hans Ulrich Bucher, Markus Rudin, Sabine Van Huffel, Ursula Wolf, Duane F. Bruley, David K. Harrison Volume 738 SELF AND NONSELF Carlos López-Larrea Volume 739 SENSING IN NATURE Carlos López-Larrea Volume 740 CALCIUM SIGNALING Md. Shahidul Islam Volume 741 STEM CELL TRANSPLANTATION Carlos López-Larrea, Antonio López Vázquez and Beatriz Suárez Álvarez Volume 742 ADVANCES IN MITROCHONDRIAL MEDICINE Roberto Scatena Volume 743 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) AND BREASTFEEDING Athena Kourtis and Marc Bulterys Volume 744 RAMPs William S. Spielman and Narayanan Parameswaran Volume 745 NEW TECHNOLOGIES FOR TOXICITY TESTING Michael Balls, Robert D. Combes and Nirmala Bhogal

A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.

New Technologies for Toxicity Testing Edited by Michael Balls, DPhil FRAME, Nottingham, UK Robert D. Combes, PhD Independent Consultant, Norwich, UK Nirmala Bhogal, PhD Independent Consultant, Nottingham, UK

Springer Science+Business Media, LLC Landes Bioscience

Springer Science+Business Media, LLC Landes Bioscience Copyright ©2012 Landes Bioscience and Springer Science+Business Media, LLC All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing         

  

         and executed on a computer system; for exclusive use by the Purchaser of the work. Printed in the USA. Springer Science+Business Media, LLC, 233 Spring Street, New York, New York 10013, USA http://www.springer.com Please address all inquiries to the publishers: Landes Bioscience, 1806 Rio Grande, Austin, Texas 78701, USA Phone: 512/ 637 6050; FAX: 512/ 637 6079 http://www.landesbioscience.com The chapters in this book are available in the Madame Curie Bioscience Database. http://www.landesbioscience.com/curie New Technologies for Toxicity Testing, edited by Michael Balls, Robert D. Combes and Nirmala Bhogal. Landes Bioscience / Springer Science+Business Media, LLC dual imprint / Springer series: Advances in Experimental Medicine and Biology. ISBN: 978-1-4614-3054-4                  of equipment and devices, as set forth in this book, are in accord with current recommendations and practice at t