New Therapies to Prevent or Cure Auditory Disorders
This volume focuses on new molecular therapies that aim to prevent specific pathologies of the ear, like age-related hearing loss, noise-induced hearing loss and ototoxicity. The book discusses the regenerative capacity of hair cells in the inner ear
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apies to Prevent or Cure Auditory Disorders
New Therapies to Prevent or Cure Auditory Disorders
Sylvie Pucheu • Kelly E. Radziwon Richard Salvi Editors
New Therapies to Prevent or Cure Auditory Disorders
Editors Sylvie Pucheu CILcare Advanced Solution for Drug Development in Hearing Disorder Montpellier, France
Kelly E. Radziwon Center for Hearing and Deafness University at Buffalo Buffalo, NY, USA
Richard Salvi Center for Hearing and Deafness University at Buffalo Buffalo, NY, USA
ISBN 978-3-030-40412-3 ISBN 978-3-030-40413-0 (eBook) https://doi.org/10.1007/978-3-030-40413-0 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Introduction
Hearing disorders affect more than 15% of people worldwide. One out of three people over 65 years of age has disabling hearing loss, with 80% of young people at significant risk of hearing impairment. The World Health Organization (WHO) estimates that by 2050, 10% of the world’s population will have disabling hearing loss. Currently, sensorineural hearing loss (SNHL) is the most common type of hearing disorder, accounting for almost 90% of reported hearing loss. SNHL is characterized by the loss of sensory hair cells in the cochlea and/or neural damage in the auditory pathway. Since hair cells cannot regenerate in the human cochlea, SNHL is permanent. Multifactorial etiologies for SNHL include aging, noisy lifestyles and work environments, infections, and more than 300 ototoxic drugs on the market, including the commonly used cancer drug cisplatin. This volume provides an up-to-date resource on the mechanisms underlying hearing disorders, including related pathologies such as tinnitus, a phantom auditor
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