New treatments in Noninfectious Uveitis. E. Miserocchi, G. Modorati, C. S. Foster. Developments in Ophthalmology Vol. 51
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BOOK REVIEW
New treatments in Noninfectious Uveitis. E. Miserocchi, G. Modorati, C. S. Foster. Developments in Ophthalmology Vol. 51 Karger Publishing, Germany, 2012, ISSN 978-3-8055-9987-0 Brandon Baartman & Shree K. Kurup
Received: 24 September 2012 / Accepted: 27 September 2012 / Published online: 11 October 2012 # Springer-Verlag Berlin Heidelberg 2012
This book is an international collaborative venture, and is addressed to the ophthalmology community in general by experts in the field. As expected from the caliber of its producers, it comprises of high quality material evaluating the current state of therapeutics. The introductory chapters are historical data that points to the easily forgotten struggles by the pioneer immunologists who attempted to tame various immunemediated conditions. The benefits and still less than well-known adverse effects of corticosteroids are wellelucidated by LeHoang. Conventional corticosteroid sparing therapy has been masterfully detailed by Foster, as well as in broad strokes by Lightman. Meticulously, the case for considering steroid-sparing drugs is also well-made. Although there is considerable overlapping amongst chapters (drugs), it is useful for the newly minted ocular immunologist to have repeated feeding of the overall schema of management with more commonly used medications. The chapter on mycophenolate is concise, and has a welllaid-out framework, since it appears that the scope and use of this drug is increasing in the ophthalmic world. The role of TNF inhibitors with emphasis on application in specific diseases or conditions has been addressed by Bodhagi et al. in the next chapter. Cautionary warnings in applicable situations such as multiple sclerosis have also been provided. The role of interferon (alpha) has been elucidated well by B. Baartman : S. K. Kurup (*) Wake Forest University Eye Ctr., Medical Center Boulevard, Winston Salem, NC 27157, USA e-mail: [email protected]
Zierhut, supported by OCT imaging of CME, a surrogate of the retinal vasculitis. Details on rituximab provided by Modorati are useful for both entry-level practitioners as well as experienced ones. Miserocchi et al. have explained the role of local therapy in the form of corticosteroids and select immunomodulatory drugs. deSmet has updated the role of intravitreal corticosteroid in the light of the MUST (Multicenter Uveitis Steroid Treatment) study. This is a very important broad perspective on the use of a surgical tool (i.e., the implant) versus immunomodulatory therapy. The pros and cons have been laid out in equipoise. In the last chapter, Nguyen et al. provides a window to look into the potential therapeutic developments and newer application of existing drugs. These are the snippets that provide a tantalizing view of the future of therapeutics in noninfectious uveitis. The thought processes of these experts, if assimilated by careful reading, would serve the diligent practitioner in application almost daily. This is a book that is suitable for easy carrying and parsing through. The words ar
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