No influence of brain-derived neurotrophic factor (BDNF) polymorphisms on treatment response in a naturalistic sample of
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ORIGINAL PAPER
No influence of brain-derived neurotrophic factor (BDNF) polymorphisms on treatment response in a naturalistic sample of patients with major depression Richard Musil • Peter Zill • Florian Seemu¨ller • Brigitta Bondy • Michael Obermeier Ilja Spellmann • Wolfram Bender • Mazda Adli • Isabella Heuser • Joachim Zeiler • Wolfgang Gaebel • Wolfgang Maier • Marcella Rietschel • Dan Rujescu • Rebecca Schennach • Hans-Ju¨rgen Mo¨ller • Michael Riedel
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Received: 29 December 2011 / Accepted: 23 August 2012 / Published online: 11 September 2012 Ó Springer-Verlag 2012
Abstract The role of the brain-derived neurotrophic factor (BDNF) in the pathophysiology of major depressive disorder (MDD) remains to be elucidated. Recent post hoc analyses indicated a potential association of three polymorphisms in the BDNF gene with worse treatment outcome in patients with the subtype of melancholic depression. We aimed at replicating these findings in a German naturalistic multicenter follow-up. Three polymorphisms in the BDNF gene (rs7103411, rs6265 (Val66Met) and rs7124442) were genotyped in 324 patients with MDD and 470 healthy controls. We applied univariate tests and logistic regression models stratifying for depression subtype and gender. The three polymorphisms were not associated with MDD as diagnosis. Further, no associations were found in univariate tests. With logistic regression, we
only found a tendency towards an association of the rs6265 (Val66Met) polymorphism with overall response to treatment (response rates: GG (val/val) \ GA (val/met) \ AA (met/met); p = 0.0129) and some gender differences for the rs6265 (Val66Met) and rs7103411 polymorphisms. Treatment outcome stratified for subtypes of depression did not differ significantly between the investigated polymorphisms or using haplotype analyses. However, results showed a tendency towards significance. At this stage, we cannot support an influence of these three polymorphisms. Further studies in larger patient samples to increase sample sizes of subgroups are warranted.
R. Musil (&) P. Zill F. Seemu¨ller B. Bondy M. Obermeier I. Spellmann D. Rujescu R. Schennach H.-J. Mo¨ller M. Riedel Department of Psychiatry and Psychotherapy, Psychiatric Clinic, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany e-mail: [email protected]
J. Zeiler Department of Psychiatry and Psychotherapy, Auguste-Viktoria-Krankenhaus, Rubensstr. 125, 12157 Berlin, Germany
W. Bender Department of Psychiatry and Psychotherapy, Isar-Amper-Klinikum Munich East, Vockestr. 72, 85540 Haar, Germany M. Adli Department of Psychiatry and Psychotherapy, Campus, Charite´ Mitte (CCM), Charite´platz 1, 10117 Berlin, Germany I. Heuser Department of Psychiatry and Psychotherapy, Campus Charite´ Benjamin Franklin (CFB), Eschenallee 3, 14050 Berlin, Germany
Keywords Pharmacogenetics BDNF gene Treatment response Major depressive disorder
W. Gaebel Department of Psychiatry and Psychotherapy, University of Du¨sseldorf, Bergische Lands
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