Non-Contact Analysis of Magnetic Fields of Biological Objects: Algorithms for Data Recording and Processing
- PDF / 879,495 Bytes
- 15 Pages / 594 x 792 pts Page_size
- 81 Downloads / 218 Views
NON-CONTACT ANALYSIS OF MAGNETIC FIELDS OF BIOLOGICAL OBJECTS: ALGORITHMS FOR DATA RECORDING AND PROCESSING M. A. Primin1† and I. V. Nedayvoda1‡
UDC 682.32+537.8
Abstract. Based on low-temperature SQUID sensors, an ultra-sensitive magnetometric system has been created for the analysis of nanoparticles in biological objects. The main features of the SQUID magnetometric system and information technology during registration and analysis of magnetic signals from organs of laboratory animals are considered. Experimental data on the operation of the magnetometric system and algorithms of data recording and processing in the study of physical models (small animals) with nanoparticles are presented. Keywords: SQUID sensor, magnetometric system, information technology, inverse problem, biological objects, nanoparticles. INTRODUCTION The vital activity of living organisms is accompanied by the magnetic field radiation. Their sources are ions that move due to the electric activity of cell membranes. Magnetic materials that participate in biological processes have different magnetic susceptibility and therefore distort applied external magnetic fields in different ways, for example, ferromagnetic and paramagnetic particles that penetrate in a certain way, or are purposefully introduced into the body. Regardless of the source type, all biomagnetic signals are rather weak, much weaker than the surrounding magnetic interference, which can exceed these signals in amplitude by 10–12 orders of magnitude. The measurement of biomagnetic signals became possible only after the creation of SQUIDs (the superconducting quantum interference devices), which have a record high sensitivity to a magnetic field (up to 10 -14 T). Lead is known to be a global anthropogenic pollutant [1]. The results of studies carried out in many countries have demonstrated the effect of low-level environmental exposure to lead on the subsequent development of diseases, such as arterial hypertension, arteriosclerosis, and ischemic heart disease [2]. The risk of developing pathologies of the cardiovascular system in the adult population is explained by the effect of cumulation of lead exposure even at low doses [3]. Therefore, an important task in medicine is to study the distribution of iron nanoparticles in the organs and tissues of small animals (physical models), taking into consideration the lead dose, the method of its administration, and the post-exposure period. This is important for the preliminary assessment of the violation of iron metabolism and its possible transfer to the liver, when lead (in the form of nanoparticles and in the form of a solution of lead acetate) and cadmium (in the form of nanoparticles) are administered to biological objects, which also causes severe consequences. In this case, an important science-intensive component, which determines the capabilities and the effectiveness of the applied use of the supersensitive SQUID magnetometric systems is the information technology developed to interpret the results of magnetometric measure
Data Loading...
