Non-invasive contrast enhanced MRI tissue characterisation early and late after heart transplantation
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POSTER PRESENTATION
Open Access
Non-invasive contrast enhanced MRI tissue characterisation early and late after heart transplantation Henning Steen*, Eva Hofmann, Hugo A Katus From 15th Annual SCMR Scientific Sessions Orlando, FL, USA. 2-5 February 2012 Background Non-invasive MRI tissue characterisation after HTX could potentially replace the hazardous myocardial biopsy for tissue staging and detection of transplant rejection. Recently, late gadolinium contrast enhanced cardiac MRI (LGE-CMR) showed infarct-typical patterns already early after HTX. Additionally, infarct-atypical LGE patterns were also shown in general but neither morphological differentiation nor its time course after HTX have been investigated. We hypothesized that MRI could detect and differentiate different forms of infarct-atypical LGE patterns and show differences in their morphological appearance during the time course after HTX. Methods 123 patients (pts) were divided into group I (62 pts; HTX operation2ys). LGE-CMR (Gadolinium:0.2mmol/kg bw) was performed on a 1.5T Whole Body MRI scanner (Philips Medical Systems) and analysed blindly by two experienced observers. For anatomic LGE description, hearts were divided according to the 17-segment model. Areas of infarct-atypical LGE patterns were classified into four types as a) LGE at the RV-insertion (inferoseptal), b) intramural, c) nodular and d) diffuse. Groups were compared using ANOVA. P-values ≤ 0.05 were considered statistically significant. Results In group I, 65% of patients and 210 of 1054 segments (20%) showed infarct-atypical LGE patterns. In contrast, significantly less patients (41%) of group II and only 54
of 1037 (both p
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