Non-radiographic axial spondyloarthritis in Tunisia: main characteristics and detailed comparison with ankylosing spondy
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ORIGINAL ARTICLE
Non-radiographic axial spondyloarthritis in Tunisia: main characteristics and detailed comparison with ankylosing spondylitis Kawther Ben Abdelghani 1,2 & Yosra Gzam 1,2 & Alia Fazaa 1,2 & Saoussen Miladi 1,2 & Meriem Sellami 1,2 & Leila Souabni 1,2 & Selma Kassab 1,2 & Selma Chekili 1,2 & Leith Zakraoui 1,2 & Ahmed Laater 1,2 Received: 9 July 2020 / Revised: 25 August 2020 / Accepted: 16 September 2020 # International League of Associations for Rheumatology (ILAR) 2020
Abstract Objectives The aim of the present study is to compare the clinical features, disease activity, and physical impairment between non-radiographic axial spondyloarthritis and ankylosing spondylitis in Tunisian patients. Methods This is a retrospective study conducted in a single rheumatology center in Tunisia. Patients with axial spondyloarthritis fulfilling the 2009 ASAS criteria were included. The various spondyloarthritis-related variables were compared between nonradiographic axial spondyloarthritis and ankylosing spondylitis. p Values below 0.05 were considered statistically significant. Results Among 200 patients with axial spondyloarthritis, 40 had non-radiographic axial spondyloarthritis and 160 had ankylosing spondylitis. The non-radiographic axial spondyloarthritis patients were more frequently female, were younger, and had shorter disease duration. Patients with non-radiographic axial spondyloarthritis experienced enthesitis more frequently compared with ankylosing spondylitis patients. Psoriasis was more frequent in non-radiographic axial spondyloarthritis group, while inflammatory bowel disease was more frequent in ankylosing spondylitis group. The C-reactive protein level and functional score were significantly higher in patients with ankylosing spondylitis compared with non-radiographic axial spondyloarthritis. Tumor necrosis factor inhibitors were offered significantly more often to the ankylosing spondylitis group. There was no statistically significant difference between the 2 groups in other spondyloarthritis parameters. Conclusion The non-radiographic axial spondyloarthritis is characterized mainly by a marked female prevalence, a higher enthesitis prevalence, and a better physical function. Key points: • Patients with nr-axSpA in Tunisia are more frequently female and have shorter disease duration compared with those with AS. • Peripheral manifestations were similar between nr-axSpA and AS patients except for enthesitis which were more frequent within nr-axSpA patients. • The disease activity is similar between the 2 groups of axSpA but the physical function is better within nr-axSpA patients.
Keywords Non-radiographic axial spondyloarthritis . Ankylosing spondylitis . Clinical features . Disease activity . Physical function
Introduction Spondyloarthritis (SpA) encompasses several chronic rheumatic diseases that share clinical features and a genetic predisposition with the association with the human leukocyte * Yosra Gzam [email protected] 1
Rheumatology Department, Mongi Slim Hospital, La Marsa,
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