Norgestimate and levonorgestrel: similar VTE risk
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Norgestimate and levonorgestrel: similar VTE risk The risk of nonfatal venous thromboembolism (VTE) appears to be similar with ethinylestradiol/norgestimate and ethinylestradiol/levonorgestrel use, and significantly increased with ethinylestradiol/desogestrel compared with ethinylestradiol/levonorgestrel use, according to US-based researchers. To compare the risk of nonfatal VTE in women receiving ethinylestradiol/norgestimate or ethinylestradiol/desogestrel with those receiving ethinylestradiol/levonorgestrel, for oral contraception, the researchers conducted a nested case-control study* using claims data from the PharMetrics database from 2000 to 2005. They identified women aged 15–39 years with (n = 281) or without** (1055) deep vein thrombosis or pulmonary embolism who were current users of one of the study drugs at diagnosis (index date); each combination contained ethinylestradiol 30µg except ethinylestradiol/norgestimate, which contained ethinylestradiol 35µg. Compared with current ethinylestradiol/ levonorgestrel users, current ethinylestradiol/ norgestimate users had a similar risk of nonfatal VTE (adjusted odds ratios 1.1; 95% CI 0.8, 1.5) and current ethinylestradiol/desogestrel users had a significantly higher risk (1.7; 1.2, 2.4). The incidence rates of VTE in women receiving ethinylestradiol/norgestimate, ethinylestradiol/desogestrel or ethinylestradiol/ levonorgestrel were 30.6 (25.5, 36.5), 53.5 (42.9, 66.0) and 27.1 (21.1, 34.3) per 100 000 woman-years, respectively. The incidence rate ratios for use of ethinylestradiol/norgestimate and ethinylestradiol/ desogestrel were 1.1 (0.8, 1.5) and 2.0 (1.4, 2.7), respectively, compared with the use of ethinylestradiol/ levonorgestrel. * funded by Johnson and Johnson ** matched by birth year and index date Jick SS, et al. Risk of nonfatal venous thromboembolism with oral contraceptives containing norgestimate or desogestrel compared with oral contraceptives 801043016 containing levonorgestrel. Contraception 73: 566-570, No. 6, Jun 2006
0114-9954/10/1112-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 29 Jul 2006 No. 1112
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