Normative values for SedLine-based processed electroencephalography parameters in awake volunteers: a prospective observ
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ORIGINAL RESEARCH
Normative values for SedLine‑based processed electroencephalography parameters in awake volunteers: a prospective observational study Alessandro Belletti1,2 · Thummaporn Naorungroj1,3 · Fumitaka Yanase1,4 · Glenn M. Eastwood1 · Laurence Weinberg5,6 · Rinaldo Bellomo1,7,8 Received: 6 April 2020 / Accepted: 2 November 2020 © Springer Nature B.V. 2020
Abstract Processed electroencephalography (pEEG) is used to monitor depth of anaesthesia and/or sedation. A novel device (SedLine®) has been recently introduced into clinical practice. However, there are no published data on baseline SedLine values for awake adult subjects. We aimed to determine baseline values for SedLine-derived parameters in eyes-open and eyes-closed states. We performed a prospective observational study in healthy volunteers. SedLine EEG-derived parameters were recorded for 2 min with eyes closed and 8 min with eyes open. We determined the overall reference range for each value, as well as the reference range in each phase. We investigated changes in recorded parameters between the two phases, and the interaction between EMG, baseline characteristics, and Patient State Index (PSI). We collected data from 50 healthy volunteers, aged 23–63 years. Median PSI was 94 (92–95) with eyes open and 88 (87–91) with eyes closed (p
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