Notch Signaling Immunity and Cancer
This book covers the broad area related to Notch-mediated regulation of the immune system and tumorigenesis. Notch signaling was originally identified as a crucial pathway to regulate cell fate choice. Subsequent studies, however, have revealed that Notch
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Notch Signaling Immunity and Cancer
Notch Signaling
Koji Yasutomo Editor
Notch Signaling Immunity and Cancer
Editor Koji Yasutomo Graduate School of Medicine Tokushima University Kuramoto Tokushima Japan
ISBN 978-981-10-4970-5 ISBN 978-981-10-4971-2 (eBook) DOI 10.1007/978-981-10-4971-2 Library of Congress Control Number: 2017950490 © Springer Nature Singapore Pte Ltd. 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Preface
I am very pleased to have had the opportunity to organize this text summarizing the current state of knowledge about Notch. This book is composed of two parts: Notch immunology and cancer biology. Experts in Notch biology summarized their own results, discussed published data, pointed out unresolved issues, and suggested future studies. Indeed, one of the purposes of this book is defining the major questions to be approached as we enter the next era of Notch biology. Notch signaling uses evolutionarily conserved cellular machinery. Notch signaling and the associated mechanisms were originally defined in the context of cell fate decisions observed in Drosophila melanogaster. Thereafter, the fundamental roles of Notch were studied in highly diverse biological processes in many organisms, including mice and humans. The complexity of Notch signaling increased after identification of multiple Notch and Notch ligands in mammals. Plus, each Notch interacts with all of the ligands, although the affinities vary. Furthermore, the interaction is regulated by sugar modulation of Notch receptors. Although those complex fields have been gradually untangled, especially by using genetically modifi
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