Novel Antischizophrenia Treatments

This volume tries to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizop

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Editor-in-Chief F.B. Hofmann, M€ unchen

Editorial Board J.A. Beavo, Seattle J.E. Barrett, Philadelphia D. Ganten, Berlin P. Geppetti, Florence M.C. Michel, Ingelheim C.P. Page, London W. Rosenthal, Berlin

For further volumes: http://www.springer.com/series/164

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Mark A. Geyer • Gerhard Gross Editors

Novel Antischizophrenia Treatments

Editors Mark A. Geyer University of California San Diego Department of Psychiatry La Jolla California USA

Gerhard Gross Abbott, Neuroscience Research, GPRD Ludwigshafen, Germany Institut f€ur Pharmakologie Universit€at Duisburg-Essen Universit€atsklinikum Essen Essen Germany

ISSN 0171-2004 ISSN 1865-0325 (electronic) ISBN 978-3-642-25757-5 ISBN 978-3-642-25758-2 (eBook) DOI 10.1007/978-3-642-25758-2 Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2012947033 # Springer-Verlag Berlin Heidelberg 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Product Liability: The publisher can give no guarantee for all the information contained in this book. This does also refer to information about drug dosage and application thereof. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. Springer is part of Springer Science+Business Media (www.springer.com)

Preface

Six decades after the serendipitous discovery