Novel biomarker of sphericity and cylindricity indices in volume-rendering optical coherence tomography angiography in n
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Novel biomarker of sphericity and cylindricity indices in volume-rendering optical coherence tomography angiography in normal and diabetic eyes: a preliminary study Peter M. Maloca 1,2,3,4 & Richard F. Spaide 5 & Emanuel Ramos de Carvalho 4 & Harald P. Studer 2 & Pascal W Hasler 2,3 & Hendrik P. N. Scholl 1,2,3,7 & Tjebo F. C. Heeren 8 & Julia Schottenhamml 6 & Konstantinos Balaskas 4,8 & Adnan Tufail 4 & Catherine Egan 4 & IOB study group Received: 27 May 2019 / Revised: 5 December 2019 / Accepted: 19 December 2019 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Preliminary to evaluate geometric indices (vessel sphericity and cylindricity) for volume-rendered optical coherence tomography angiography (OCTA) in healthy and diabetic eyes. Methods Twenty-six eyes of 13 healthy subjects and 12 eyes of patients with central ischemic, non-proliferative diabetic retinopathy were included. OCTA volume and surface area of the foveal vessels were measured and compared to determine OCTA sphericity and cylindricity indices and surface efficiency (SE). Results The overall average OCTA volume in healthy was 0.49 ± 0.09 mm3 (standard deviation [SD]), compared to 0.44 ± 0.07 mm3 (SD) in the diabetic eyes (difference in means 0.06 mm3, p = 0.054). The overall average OCTA surface area in the healthy eyes was 87.731 ± 9.51 mm2 (SD), compared to 76.65 ± 13.67 mm2 (SD) in the diabetic eyes (difference in means 11.08 mm2, p = 0.021). In relation to total foveolar tissue volume, the proportion of blood vessels was 22% in healthy individuals and only 20% in diabetics. The difference between the groups was more pronounced with respect to the total OCTA surface area, with a decrease of 13% in diabetics. A diabetic eye was most likely using geometric vessel indices analysis if the sphericity value was ≥ 0.190, with a cylindricity factor of ≥ 0.001. Reproducibility of the method was good. Conclusions A method for OCTA surface area and volume measurements was developed. The application of the novel OCTA sphericity and cylindricity indices could be suitable as temporal biomarker to characterize stable disease or disease progression and may contribute to a better understanding in the evolution of diabetic retinopathy. Keywords Diabetes . Retina . Optical coherence tomography angiography . Volume-rendering . Sphericity . Cylindricity
* Peter M. Maloca [email protected] 1
Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland
2
Department of Ophthalmology, OCTlab, University Hospital Basel, Basel, Switzerland
3
Department of Ophthalmology, University of Basel, Basel, Switzerland
4
Moorfields Eye Hospital, London, UK
5
Vitreous Retina Macula Consultants, New York City, NY, USA
6
Pattern Recognition Lab, University Erlangen-Nürnberg, Erlangen, Germany
7
Wilmer Eye Institute, Johns Hopkins University, Baltimore, USA
8
Moorfields Ophthalmic Reading Centre, London, UK
Introduction Optical coherence tomography angiography (OCTA) is a noninvasive imaging tech
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