NSAIDs and Aspirin Recent Advances and Implications for Clinical Man
This volume is a state-of-the art resource on the recent advances and clinical management of NSAIDs and aspirin. The text provides a thorough overview of NSAIDS and aspirin, reviewing such topics as pharmacology and mechanisms, clinical effects, and the s
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NSAIDs and Aspirin Recent Advances and Implications for Clinical Management
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NSAIDs and Aspirin
Angel Lanas Editor
NSAIDs and Aspirin Recent Advances and Implications for Clinical Management
Editor Angel Lanas Universidad de Zaragoza IIS Arago´n, CIBER Enfermedades Hepa´icas y Digestivas (CIBERehd) Zaragoza, Spain Service of Digestive Diseases University Hospital Lozano Blesa Zaragoza, Spain
ISBN 978-3-319-33887-3 ISBN 978-3-319-33889-7 (eBook) DOI 10.1007/978-3-319-33889-7 Library of Congress Control Number: 2016945854 # Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface
NSAIDs are one of the most widely prescribed drugs around the world to treat pain and inflammation. Prescribers of these drugs include a wide range of medical specialties, including general practitioners, rheumatologists, oncologists, orthopedists, and trauma and internal medicine specialists. Gastroenterologists have a special interest on these compounds based on the gastrointestinal adverse events derived from their use and the recent data on colorectal cancer prevention with aspirin and NSAIDs. The field has underwent great changes and outstanding new advances in the last 10 years, which have changed the prescription habits, guidelines, and new restrictions and recommendations made by international regulatory agencies such as the FDA or the EMA. The knowledge and advances have been produced essentially since the development of the new class of drugs that inhibited selectively the COX-2 isozyme. The clinical use of these new compounds uncovered adverse effects that had been hidden to the eyes of investigators. In this way, today we know that the use of either COX-2 selective inhibitors or traditional NSAIDs is associated with adverse events not only from the upper GI tract but from
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