Numerical investigation of patient-specific thoracic aortic aneurysms and comparison with normal subject via computation
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ORIGINAL ARTICLE
Numerical investigation of patient-specific thoracic aortic aneurysms and comparison with normal subject via computational fluid dynamics (CFD) Mustafa Etli 1 & Gokhan Canbolat 2
&
Oguz Karahan 1 & Murat Koru 3
Received: 17 May 2020 / Accepted: 5 November 2020 # International Federation for Medical and Biological Engineering 2020
Abstract Vascular hemodynamics play an important role in cardiovascular diseases. This work aimed to investigate the effects of an increase in ascending aortic diameter (AAD) on hemodynamics throughout a cardiac cycle for real patients. In this study, two scans of thoracic aortic aneurysm (TAA) subject with different AADs (42.94 mm and 48.01 mm) and a scan of a normal subject (19.81 mm) were analyzed to assess the effects of hemodynamics on the progression of TAA with the same flow rate. Realpatient aortic geometries were scanned by computed tomography angiography (CTA), and steady and pulsatile flow conditions were used to simulate real patient aortic geometries. Aortic arches were obtained from routine clinical scans. Computational fluid dynamics (CFD) simulations were performed with in vivo boundary conditions, and 3D Navier-Stokes equations were solved by a UDF (user-defined function) code defining a real cardiac cycle of one patient using Fourier series (FS). Wall shear stress (WSS) and pressure distributions were presented from normal subject to TAA cases. The results show that during the peak systolic phase pressure load increased by 18.56% from normal subject to TAA case 1 and by 23.8% from normal subject to TAA case 2 in the aneurysm region. It is concluded that although overall WSS increased in aneurysm cases but was low in dilatation areas. As a result, abnormal changes in WSS and higher pressure load may lead to rupture and risk of further dilatation. CFD simulations were highly effective to guide clinical predictions and assess the progress of aneurysm regions in case of early surgical intervention. Keywords Computational fluid dynamics (CFD) . Thoracic aortic aneurysm . Cardiovascular flow . Computed tomography angiography . Patient-specific simulation
1 Introduction The combination of medical imaging and computational fluid dynamics (CFD) has become an important tool to study hemodynamics on vascular structures [1]. Forces and stresses produced by the blood flow on the arteries cause initialization
* Gokhan Canbolat [email protected] 1
Department of Cardiovascular Surgery, Alanya Alaaddin Keykubat University, Antalya, Turkey
2
Department of Mechanical Engineering, Alanya Alaaddin Keykubat University, Antalya, Turkey
3
Department of Mechanical Engineering Applied Science University of Isparta, Isparta, Turkey
and localization of different cardiovascular diseases [2]. The aorta, which serves as the transmission of blood from the heart to all organs in the body, is the biggest artery in cardiovascular system. An aortic aneurysm (AA) represents the progressive weakening of the aortic wall in the aneurysm region. Thoracic aortic aneurysm
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